Genetics of vascular dementia - review from the ICVD working group

Autor: Helena Schmidt, Benedetta Nacmias, Raquel Manso-Calderón, Anna Bersano, M. Arfan Ikram, Lefkos T. Middleton, Hieab H.H. Adams, Saima Siddiqi, Jianping Jia
Přispěvatelé: Epidemiology, Neurology, Radiology & Nuclear Medicine
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Cerebral small vessel disease
Review
Disease
SMALL-VESSEL DISEASE
CEREBROVASCULAR-DISEASE
Vascular dementia
03 medical and health sciences
Disease susceptibility
Genetics
Magnetic resonance imaging
Medicine (all)
Apolipoproteins E
Medicine
General & Internal
0302 clinical medicine
General & Internal Medicine
mental disorders
WHITE-MATTER HYPERINTENSITIES
Humans
Medicine
GENOME-WIDE ASSOCIATION
DRUG DEVELOPMENT
Stroke
Medicine(all)
FABRY-DISEASE
Polymorphism
Genetic
Science & Technology
Aryldialkylphosphatase
business.industry
Dementia
Vascular
NECROSIS-FACTOR-ALPHA
11 Medical And Health Sciences
General Medicine
COGNITIVE IMPAIRMENT
medicine.disease
3. Good health
ALZHEIMERS-DISEASE
Clinical Practice
030104 developmental biology
Disease Progression
Dementia
CEREBRORETINAL VASCULOPATHY
Small vessel
business
Life Sciences & Biomedicine
030217 neurology & neurosurgery
Zdroj: BMC Medicine, 15:48. BioMed Central Ltd.
BMC Medicine
ISSN: 1741-7015
Popis: Background: Vascular dementia is a common disorder resulting in considerable morbidity and mortality. Determining the extent to which genes play a role in disease susceptibility and their pathophysiological mechanisms could improve our understanding of vascular dementia, leading to a potential translation of this knowledge to clinical practice. Discussion: In this review, we discuss what is currently known about the genetics of vascular dementia. The identification of causal genes remains limited to monogenic forms of the disease, with findings for sporadic vascular dementia being less robust. However, progress in genetic research on associated phenotypes, such as cerebral small vessel disease, Alzheimer’s disease, and stroke, have the potential to inform on the genetics of vascular dementia. We conclude by providing an overview of future developments in the field and how such work could impact patients and clinicians. Conclusion: The genetic background of vascular dementia is well established for monogenic disorders, but remains relatively obscure for the sporadic form. More work is needed for providing robust findings that might eventually lead to clinical translation.
Databáze: OpenAIRE
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