Expression of nestin in superior cervical ganglia of rats is influenced by gender and gonadectomy
| Autor: | Tomislav Mašek, Natalija Filipović, Ivica Grković |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Superior cervical ganglion medicine.medical_specialty Neurogenesis Ovariectomy Period (gene) Superior Cervical Ganglion superior cervical ganglion nestin satellite cells age gender gonadectomy Biology Nestin Rats Sprague-Dawley Cellular and Molecular Neuroscience Age groups Internal medicine Image Processing Computer-Assisted medicine Animals Sexual maturity Sex Characteristics Immunohistochemistry Neural stem cell Rats Endocrinology medicine.anatomical_structure nervous system Cervical ganglia Female Orchiectomy Hormone |
| Zdroj: | Journal of Chemical Neuroanatomy. 63:6-12 |
| ISSN: | 0891-0618 |
| DOI: | 10.1016/j.jchemneu.2014.11.003 |
| Popis: | Neurons and glia arise from neural progenitor cells that express nestin. Although substantial changes in neuronal development were observed during the postnatal period, data concerning dynamics of nestin expression in the superior cervical ganglia (SCG) of rat during that period are lacking. It is known that gonadectomy and steroid hormones influence the development of neurons in the SCG during the postnatal period, but there are no data on how they influence the persistence of nestin expression in the SCG cells. The dynamics of nestin expression in the SCG in rats of three age groups, as well as the influence of gender and gonadectomy, was investigated. Three groups of male rats were sacrificed at 2, 3 and 6 months of age. Additional groups of male and female Sprague-Dawley rats were gonadectomized at the age of 2 months. After 30 days, they were sacrificed and SCGs were harvested and processed immunohistochemically. Immunoreactivity for nestin in the SCG was observed in satellite glia, based on their expression of s100. The proportion of neurons that were encircled with nestin-immunoreactive satellite cells (nestin encircled neurons, NEN) decreased between second and third month of age (p |
| Databáze: | OpenAIRE |
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