Role of blood pressure, uric acid, and hemorheological parameters on plasma homocyst(e)ine concentration
| Autor: | M.R. Malinow, Philippe Giral, P. Segond, Jaime Levenson, F.J. Nieto, Mahmoud Razavian, Alain Simon |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Homocysteine Systolic hypertension Hemodynamics Blood Pressure Hematocrit chemistry.chemical_compound High-density lipoprotein Internal medicine Blood plasma medicine Humans medicine.diagnostic_test business.industry Middle Aged medicine.disease Uric Acid Endocrinology Blood pressure chemistry Hypertension Multivariate Analysis Uric acid Cardiology and Cardiovascular Medicine business Blood Flow Velocity |
| Zdroj: | Atherosclerosis. 114(2) |
| ISSN: | 0021-9150 |
| Popis: | Elevated concentration of plasma homocyst(e)ine is an independent risk factor for clinical atherosclerosis. In this study, the concentration of plasma homocyst(e)ine in men who lacked a history of atherosclerotic disease was correlated with hemodynamic, rheological and biochemical parameters. Hypertensive subjects had higher concentrations of plasma homocyst(e)ine than normotensive subjects. Positive correlations were found between concentrations of plasma homocyst(e)ine and several risk factors, but some of these correlations disappeared when they were adjusted for other variables. However, multivariate analyses demonstrated that systolic blood pressure, plasma uric acid, and hematocrit were predictors of concentrations of plasma homocyst(e)ine, after adjusting for certain risk factors. The possible significance of these interrelationships in atherogenesis require further study. |
| Databáze: | OpenAIRE |
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