Steroid-free Liver Transplantation Using Rabbit Antithymocyte Globulin Induction in 500 Consecutive Patients
| Autor: | James D. Eason, Luis Campos, Nosratollah Nezakatgoo, Kian A. Modanlou, Jason M. Vanatta, Satheesh Nair, Min C. Yoo |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty T-Lymphocytes medicine.medical_treatment Urology Renal function Liver transplantation Tacrolimus Cohort Studies chemistry.chemical_compound Liver disease medicine Animals Humans Methylprednisolone Hemisuccinate Prospective Studies Antilymphocyte Serum Proportional Hazards Models Transplantation Creatinine business.industry Graft Survival Immunosuppression Middle Aged Mycophenolic Acid medicine.disease Liver Transplantation surgical procedures operative chemistry Sirolimus Female Steroids Rabbits business Immunosuppressive Agents medicine.drug |
| Zdroj: | Transplantation. 99:1231-1235 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/tp.0000000000000477 |
| Popis: | BACKGROUND We have previously documented the efficacy of a steroid-free immunosuppression protocol using rabbit antithymocyte globulin (RATG) induction in orthotopic liver transplantation (OLT) with tacrolimus minimization. The purpose of this report is to demonstrate the benefits of this protocol in a large cohort of patients. METHODS We evaluated outcomes of 500 consecutive OLT recipients who received RATG induction and a single dose of solumedrol given before the first dose of RATG. Mycophenolate mofetil was initiated postoperatively with delayed initiation of tacrolimus. Sirolimus replaced tacrolimus if serum creatinine remained above 2.0 mg/dL by day 7. Patients were weaned to tacrolimus or sirolimus monotherapy at 3 months. Mean model for end-stage liver disease (MELD) at transplantation was 22 ± 6. RESULTS Forty-four percent of patients had hepatitis C. Posttransplant creatinine was highest at 1 month (1.43 ± 0.95 mg/dL) and improved to 1.26 ± 0.60 mg/dL (P < 0.05) at 2.5 years. Glomerular filtration rate was lowest at 1 month (65.6 ± 30.0) and improved by 1 year (72.7 ± 28.2, P < 0.01). Tacrolimus was initiated at 4.79 ± 13.3 days with a level of 4.95 ± 2.45 ng/mL at 1 year. One-year patient and graft survival were 92.8% and 89.6%, respectively, with a 3-year patient survival of 82.9%. Rejection occurred in 114 (22.8%) patients, 33 (6.6%) patients requiring steroids. Univariate and multivariate Cox proportional hazard analyses were performed to evaluate the effects of donor and recipient characteristics on patient and graft survivals. Pretransplant creatinine was consistently a statistically significant predictor for patient and graft survival. CONCLUSION This is the largest reported series of OLT recipients using a steroid-free protocol with RATG induction demonstrating excellent outcomes, low complication rates, and preservation of renal function. |
| Databáze: | OpenAIRE |
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