Restorative Therapies for Erectile Dysfunction: Position Statement From the Sexual Medicine Society of North America (SMSNA)
| Autor: | Gerald B. Brock, Kelvin P. Davies, James Liu, Trinity J. Bivalacqua, Ranjith Ramasamy, Andrew T. Gabrielson, John P. Mulhall, Run Wang, Landon Trost, Gregory A. Broderick, Kevin Y. Chu |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Position statement
medicine.medical_specialty LiSWT Low-intensity shock wave therapy Restorative therapies Stromal vascular fraction Urology Endocrinology Diabetes and Metabolism 030232 urology & nephrology Dermatology Disease IIEF International Index of Erectile Function 03 medical and health sciences Behavioral Neuroscience Other systems of medicine 0302 clinical medicine Endocrinology Sexual medicine Medicine Society Report EHS Erection Hardness Score Erectile dysfunction Intensive care medicine Adverse effect Stem cell therapy 030219 obstetrics & reproductive medicine SVF Stromal vascular fraction business.industry Outcome measures medicine.disease SHIM Sexual Health Inventory for Men SCT stem cell therapy Clinical trial Psychiatry and Mental health Reproductive Medicine ED Erectile dysfunction PDE5i phosphodiesterase type 5 inhibitor PRP Platelet-rich plasma Platelet rich plasma business Sexual function Low intensity shock wave therapy RZ201-999 |
| Zdroj: | Sexual Medicine Sexual Medicine, Vol 9, Iss 3, Pp 100343-(2021) |
| ISSN: | 2050-1161 |
| Popis: | Introduction Current non-invasive treatments for erectile dysfunction (ED) include oral medications, intracavernosal injections, and vacuum-assisted devices. Though these therapies work well for many, a subset of patients have contraindications or are unsatisfied with these options. Restorative therapies for ED are a new frontier of treatments focused on regenerating diseased tissue and providing a potential “cure” for ED. Aim The aim of this position statement is to examine existing clinical trial data for restorative therapies and identify elements that require further research before widespread adoption. Methods A literature review was performed to identify all clinical trials performed with regenerative therapy for ED. This includes treatments such as stem cell therapy (SCT), platelet rich plasma (PRP), and restorative related technologies like low-intensity shockwave therapy (LiSWT). Main Outcome Measures Most clinical trials in restorative therapies were assessed for safety, feasibility, or efficacy. This included recording adverse events, changes in sexual function and erectile function questionnaires, and diagnostics measures. Results To date there is an absence of robust clinical data supporting the efficacy of restorative therapies regarding ED, though technologies such as LiSWT have established relative safety. Conclusions Restorative therapies are a promising technology that represents a new frontier of treatment geared towards reversing disease pathology rather than just treating symptoms. However, current published clinical studies are limited. Future work needs to be adequately powered, multi-center, randomized, sham/placebo-controlled trials in well-characterized patient populations to ensure safety and demonstrate efficacy. Until these studies are done, restorative therapies should be reserved for clinical trials and not offered in routine clinical practice. |
| Databáze: | OpenAIRE |
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