The effects of daily bathing of neonatal rhesus monkeys with an antimicrobial skin cleanser containing chlorhexidine gluconate
| Autor: | L.E. Gongwer, E.R. Hart, K. Hubben, B.Y. Cockrell, R.S. Lenkiewicz |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Pathology
medicine.medical_specialty Bathing Adipose tissue Physiology Urine Absorption (skin) Toxicology Cerebrospinal fluid medicine Animals Tissue Distribution Feces Skin Pharmacology business.industry Body Weight Chlorhexidine Baths Haplorhini Antimicrobial Macaca mulatta Animals Newborn business medicine.drug |
| Zdroj: | Toxicology and Applied Pharmacology. 52:255-261 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(80)90112-x |
| Popis: | Five neonatal rhesus monkeys were bathed daily for 90 days with an antimicrobial skin cleanser containing 8% chlorhexidine gluconate (twice the concentration in normal use). A similar group of neonates was bathed with the skin cleanser formulation without chlorhexidine, and a third group was bathed with tap water only. The infants tolerated the bathing well. Individual variations in live weight gain and in hematologic and serum chemistry values were not associated wtih treatment. There were no gross lesions at termination. Microscopic examination of selected tissues showed changes that were evaluated as artifactual, developmental, or resulting from individual variations. Samples of blood taken 2 hr after washing at the end of 1, 4, and 8 weeks of washing showed no detectable level of chlorhexidine (limit of detection was 11 ng/ml). Terminal samples of blood (with the exception of one monkey), bile, bladder urine, brain, cerebrospinal fluid, and lungs contained no detectable level of chlorhexidine. Samples of adipose tissue ( 2 5 ), kidneys ( 5 5 ), liver ( 1 5 ), and intestinal feces ( 2 5 ) showed trace amounts of chlorhexidine, and samples of skin showed an appreciable amount of the compound. This latter finding suggests that the very low tissue levels found in some of the animals may have arisen through oral ingestion following grooming. It is apparent that absorption of chlorhexidine through the intact skin of neonatal monkeys is quite low or negligible and that the repeated daily washing with a skin cleanser containing twice the concentration of chlorhexidine gluconate in normal use caused no measurable or recognizable effect on the health of the animal or on the integrity of its tissues. |
| Databáze: | OpenAIRE |
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