Brain alterations in autoimmune and pharmacological models of diabetes mellitus: focus on hypothalamic-pituitary-adrenocortical axis disturbances
| Autor: | A. F. De Nicola, Flavia Saravia, Juan Beauquis, Yanina Revsin, Françoise Homo-Delarche |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Vasopressin Hypothalamo-Hypophyseal System CIENCIAS MÉDICAS Y DE LA SALUD Immunology Central nervous system Encephalopathy STREPTOZOTOCIN Neurociencias Pituitary-Adrenal System HYPOTHALAMIC-PITUITARY-ADRENAL AXIS VASOPRESSIN Endocrine System Diseases Hippocampus ASTROCYTES NEUROGENESIS Endocrinology Internal medicine Diabetes mellitus medicine Animals Humans Gliosis GLUCOCORTICOIDS Glucocorticoids Type 1 diabetes Endocrine and Autonomic Systems NONOBESE DIABETIC MICE Patología medicine.disease Disease Models Animal Medicina Básica medicine.anatomical_structure Diabetes Mellitus Type 1 Neurology Hypothalamus HIPPOCAMPUS Encephalitis HYPOTHALAMUS TYPE 1 DIABETES medicine.symptom Psychology Hypothalamic–pituitary–adrenal axis |
| Popis: | Type 1 diabetes (T1D) is linked to an 'encephalopathy' explained by some features common to the aging process, degenerative and functional disorders of the central nervous system. In the present study we describe a manifest hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis in two different experimental mouse models of T1D including the pharmacological one induced by streptozotocin and the spontaneous NOD (nonobese diabetic mice). The high expression of hypothalamic hormones like oxytocin and vasopressin were part to this alteration, together with elevated adrenal glucocorticoids and prominent susceptibility to stress. In the hippocampus of diabetic animals a marked astrogliosis, often associated with neural damage, was present. Dentate gyrus neurogenesis was also affected by the disease: proliferation and differentiation measured by bromodeoxyuridine immunodetection were significantly reduced in both experimental models used. Several facts, including changes associated with chronic hyperglycemia, hyperstimulation of the HPA axis, increased levels of circulating glucocorticoids in combination with brain inflammation and low production of new neurons, contribute to emphasize the impact of diabetes on the central nervous system. Fil: Beauquis, Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Homo Delarche, Francoise. Université Paris Diderot - Paris 7; Francia. Inserm; Francia Fil: Revsin, Yanina. Leiden University; Países Bajos Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina Fil: Saravia, Flavia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina |
| Databáze: | OpenAIRE |
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