Mu-opioid peptide (MOP) and nociceptin/orphanin FQ peptide (NOP) receptor activation both contribute to the discriminative stimulus properties of cebranopadol in the rat
| Autor: | Thomas M. Tzschentke, Kris Rutten |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Agonist Indoles Reinforcement Schedule medicine.drug_class Narcotic Antagonists NOP Receptors Opioid mu Pharmacology Generalization Psychological Nociceptin Receptor 03 medical and health sciences Cellular and Molecular Neuroscience Discrimination Psychological 0302 clinical medicine Piperidines medicine Animals Rats Long-Evans Spiro Compounds Receptor Opioid peptide Dose-Response Relationship Drug Naloxone Chemistry Cebranopadol Receptor antagonist Rats Nociceptin receptor 030104 developmental biology Opioid Peptides Opioid Receptors Opioid Conditioning Operant Benzimidazoles Cues 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuropharmacology. 129:100-108 |
| ISSN: | 0028-3908 |
| Popis: | The novel potent analgesic cebranopadol is an agonist at nociceptin/orphanin FQ peptide (NOP) and classical opioid receptors, with the highest in-vitro activity at NOP and mu-opioid peptide (MOP) receptors, and somewhat lower activity at kappa-opioid peptide (KOP) and delta-opioid peptide (DOP) receptors. We addressed the question of which of these pharmacological activities contribute to the stimulus properties of cebranopadol using a rat drug discrimination procedure. First, cebranopadol was tested in generalization tests against a morphine cue, including receptor-specific antagonism. Second, cebranopadol was established as a cue, and MOP, NOP, KOP and DOP receptor-selective agonists were tested in generalization tests. Third, cebranopadol in combination with receptor-selective antagonists was tested against the cebranopadol cue. Cebranopadol generalized to the morphine cue. Full generalization was only seen at clearly supra-analgesic doses. The effect of cebranopadol was reduced by naloxone, but was enhanced by the NOP receptor antagonist J-113397. In cebranopadol-trained rats, cebranopadol as well as morphine produced generalization. A NOP receptor agonist did not, while a DOP receptor agonist and a KOP receptor agonist weakly generalized to the cebranopadol cue. Conversely, generalization of cebranopadol was reduced by naloxone and J-113397, but not by a DOP or a KOP receptor antagonist. These results suggest a contribution of MOP receptor activity and a relative lack of contribution of DOP and KOP receptor activity to cebranopadol's stimulus properties. The findings regarding the contribution of NOP receptor activity were equivocal, but interestingly, the morphine-like stimulus property of cebranopadol appears to be reduced by its intrinsic NOP receptor activity. |
| Databáze: | OpenAIRE |
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