Lack of effects oftrans fatty acids on eicosanoid biosynthesis with adequate intakes of linoleic acid
| Autor: | J. L. Zevenbergen, E. Haddeman |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Blood Platelets
Male Platelet Aggregation Linoleic acid Phospholipid Arachidonic Acids Biochemistry Linoleic Acid chemistry.chemical_compound Isomerism Eicosanoic Acids Animals Aorta Phospholipids Unsaturated fatty acid chemistry.chemical_classification Arachidonic Acid Fatty Acids Organic Chemistry Nutritional Requirements Fatty acid Rats Inbred Strains Cell Biology Dietary Fats Epoprostenol Rats Linoleic Acids chemistry Eicosanoid Saturated fatty acid Arachidonic acid Collagen Hydroxy Acids Polyunsaturated fatty acid |
| Zdroj: | Lipids. 24:555-563 |
| ISSN: | 1558-9307 0024-4201 |
| Popis: | The minimum requirement of linoleic acid to prevent effects of dietary C18trans fatty acids on eicosanoid biosynthesis in rats was assessed. In a first experiment, six groups of animals were fed diets with a high content oftrans fatty acids [20% of energy (en%)], and increasing amounts of linoleic acid (0.4 to 7.1 en%). In a second experiment, four groups of rats were fed diets designed to comparetrans fatty acids with saturated andcis-monounsaturated fatty acids of the same chain length at the 2 en% linoleic acid level. After 9–14 weeks the biosynthesis of prostacyclin by pieces of aorta and the biosynthesis of hydroxy-heptadecatrienoic acid and 12-hydroxy-eicosatetraenoic acid by platelets were measured. The fatty acid compositions of aorta phospholipid and platelet lipid were also determined. Both the prostacyclin-production by aorta pieces and the production of hydroxy-heptadecatrienoic acid and 12-hydroxy-eicosatetraenoic acid by platelets appeared to be a linear function of the arachidonic acid level in aorta phospholipid and platelet lipid, irrespective of thetrans fatty acid content in the diet. This indicates thattrans fatty acids do not directly influence enzymes involved in eicosanoid biosynthesis. In a direct comparison withcis-monounsaturated or saturated fatty acids with 2 en% linoleic acid in the diet, only a moderate reduction in arachidonic acid level in aorta phospholipids in the group fedtrans fatty acids was observed. The geometry of the double bond did not influence the arachidonic acid level in platelet lipid, although the diet rich in saturated fatty acids increased arachidonic acid levels significantly compared with all other diets. Neither prostacyclin-production nor hydroxy-heptadecatrienoic acid or 12-hydroxy-eicosatetraenoic acid-production were significantly affected bytrans fatty acids when 2 en% linoleic acid was present in the diet. Our study indicates that in rats 2 en% linoleic acid is sufficient to prevent effects of dietarytrans fatty acids on eicosanoid synthesis. |
| Databáze: | OpenAIRE |
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