Treatment of adenoid cystic carcinoma of the breast: Is postoperative radiation getting its due credit?
| Autor: | Alan T. Davis, Tolutope Oyasiji, Andrew Gomez-Seoane |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Survival Adenoid cystic carcinoma medicine.medical_treatment Seer database Breast Neoplasms Ajcc stage Kaplan-Meier Estimate Statistical significance Internal medicine medicine Humans Breast RC254-282 Mastectomy Neoplasm Staging Radiation business.industry Nodal metastasis Postoperative radiation Neoplasms. Tumors. Oncology. Including cancer and carcinogens General Medicine medicine.disease Carcinoma Adenoid Cystic Survival Rate stomatognathic diseases Surgery Female Original Article business SEER Program |
| Zdroj: | The Breast : Official Journal of the European Society of Mastology Breast, Vol 59, Iss, Pp 358-366 (2021) |
| ISSN: | 1532-3080 |
| Popis: | Introduction The role of postoperative radiation (PR) in treating mammary ACC is poorly defined. This study evaluated the impact of PR on survival outcomes for mammary ACC and the extent of utilization. Methods Patients who underwent surgery for mammary ACC from 2005 to 2015 in SEER database were analyzed. KM analyses of OS and DSS were done for PR versus no PR. Cox hazard regression models were used to determine predictors of OS and DSS. Results Of the 488 patients, 244 underwent PR. The PR group was younger, but other variables were similar between the 2 groups. OS was better for PR (p = 0.029). 10-year DSS was better for PR group by an absolute value of 6 % but did not reach statistical significance (p = 0.537). Age, radiation, nodal metastasis, and grade III/IV were independent predictors of OS while grade III/IV and AJCC stage III/IV independently predicted DSS. Conclusion PR improves OS for mammary ACC, but this study did not show increased utilization. Radiation should be considered after surgery for mammary ACC, particularly for patients with independent predictors of OS. Highlights • The role of postoperative radiation (PR) in the management of mammary adenoid cystic carcinoma (ACC) is still poorly defined. • Postoperative radiation improves OS for mammary ACC. • Despite previous studies demonstrating benefits of PR, this study did not show increased use of the treatment modality. • PR should be considered for mammary ACC, particularly for patients with negative independent predictors of OS. |
| Databáze: | OpenAIRE |
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