Properties of ginseng saponin inhibition of catecholamine secretion in bovine adrenal chromaffin cells
| Autor: | Eiji Takahashi, Kenzo Kudo, Takeshi Kashimoto, Eiichi Tachikawa |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Sapogenins Ginsenosides Digitoxin Chromaffin Cells Saponin Panax Sapogenin Biology Cardiac Glycosides chemistry.chemical_compound Ginseng Catecholamines Internal medicine medicine Animals Oleanolic Acid Pharmacology chemistry.chemical_classification Plants Medicinal Dose-Response Relationship Drug Anti-Inflammatory Agents Non-Steroidal Panaxatriol Saponins Glycyrrhizic Acid Antineoplastic Agents Phytogenic medicine.anatomical_structure Endocrinology chemistry Ginsenoside Chromaffin cell Catecholamine Cattle Central Nervous System Agents medicine.drug |
| Zdroj: | European Journal of Pharmacology. 341:139-144 |
| ISSN: | 0014-2999 |
| Popis: | To investigate the relationship between the inhibitory effects of ginseng saponins (ginsenosides) on acetylcholine-evoked secretion of catecholamines and the structures of ginsenosides, we examined the effects of ginsenoside-Rg3 and -Rh2, which are panaxadiol saponins, 20(R)- and 20(S)-ginsenoside-Rg2, which are epimers involving the hydroxyl group at C-20 of sapogenin, and other plant saponins on the acetylcholine-evoked secretion of catecholamines from cultured bovine adrenal chromaffin cells. The ginsenoside-Rg3 (1-100 microM) and -Rh2 (10-100 microM) greatly reduced the acetylcholine-evoked secretion in a concentration-dependent manner comparable to that of ginsenoside-Rg2, a panaxatriol saponin, which was the most potent inhibitor in our previous study. 20(R)- and 20(S)-ginsenoside-Rg2 (1-100 microM) similarly reduced the acetylcholine-evoked secretion. In contrast, saikosaponin-a, glycyrrhizin and the cardiac glycosides (100 nM-100 microM), digitoxin and digoxin, had no significant inhibitory effect on catecholamine secretion. Saikosaponin-c (10-100 microM), however, had an inhibitory effect, which was less than that of ginsenoside-Rg2 and -Rg3. These results strongly suggest that the inhibitory effects of ginsenosides on the acetylcholine-evoked secretion of catecholamines from bovine adrenal chromaffin cells are a unique property of ginseng. Further, the relationship between the inhibitory effects and the structures of ginsenosides is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect