Application of electrospun nanofibers in bone, cartilage and osteochondral tissue engineering
| Autor: | Xiaolian Niu, Yizhu Cheng, Yinchun Hu, Huixiu Ding |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Scaffold
Materials science Biocompatibility 0206 medical engineering Nanofibers Biomedical Engineering Biophysics Bioengineering 02 engineering and technology Bone and Bones Biomaterials Extracellular matrix Tissue engineering medicine Tissue Engineering Tissue Scaffolds Cartilage Cell migration 021001 nanoscience & nanotechnology 020601 biomedical engineering Electrospinning medicine.anatomical_structure Nanofiber 0210 nano-technology Biomedical engineering |
| Zdroj: | Journal of Biomaterials Science, Polymer Edition. 32:536-561 |
| ISSN: | 1568-5624 0920-5063 |
| DOI: | 10.1080/09205063.2020.1849922 |
| Popis: | Tissue damage related to bone and cartilage is a common clinical disease. Cartilage tissue has no blood vessels and nerves. The limited cell migration ability results in low endogenous healing ability. Due to the complexity of the osteochondral interface, the clinical treatment of osteochondral injury is limited. Tissue engineering provides new ideas for solving this problem. The ideal tissue engineering scaffold must have appropriate porosity, biodegradability and specific functions related to tissue regeneration, especially bioactive polymer nanofiber composite materials with controllable biodegradation rate and appropriate mechanical properties have been getting more and more research. The nanofibers produced by electrospinning have high specific surface area and suitable mechanical properties, which can effectively simulate the natural extracellular matrix (ECM) of bone or cartilage tissue. The composition of materials can affect mechanical properties, plasticity, biocompatibility and degradability of the scaffold, thereby further affect the repair efficiency. This article reviews the characteristics of polymer materials and the application of its electrospun nanofibers in bone, cartilage and osteochondral tissue engineering. |
| Databáze: | OpenAIRE |
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