Comparison of Surfactants Used to Prepare Aqueous Perfluoropentane Emulsions for Pharmaceutical Applications
| Autor: | Genyao Lin, Praveena Mohan, Jules J. Magda, Mikhail Skliar, Madhuvanthi A. Kandadai, Anthony Butterfield |
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| Rok vydání: | 2010 |
| Předmět: |
Ammonium bromide
Polymers Polyesters Article Polyethylene Glycols Surface tension Surface-Active Agents chemistry.chemical_compound Pulmonary surfactant Electrochemistry Animals Organic chemistry General Materials Science Lactic Acid Spectroscopy chemistry.chemical_classification Fluorocarbons Aqueous solution Chemistry Serum Albumin Bovine Surfaces and Interfaces Polymer Models Theoretical Condensed Matter Physics Chemical engineering Emulsion Drug delivery Cattle Emulsions Dispersion (chemistry) Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Langmuir. 26:4655-4660 |
| ISSN: | 1520-5827 0743-7463 |
| DOI: | 10.1021/la100307r |
| Popis: | Perfluoropentane (PFP), a very hydrophobic, nontoxic, noncarcinogenic fluoroalkane, has generated much interest in biomedical applications, including occlusion therapy and controlled drug delivery. For most of these applications, the dispersion within aqueous media of a large quantity of PFP droplets of the proper size is critically important. Surprisingly, the interfacial tension of PFP against water in the presence of surfactants used to stabilize the emulsion has rarely, if ever, been measured. In this study, we report the interfacial tension of PFP in the presence of surfactants used in previous studies to produce emulsions for biomedical applications: polyethylene oxide-co-polylactic acid (PEO-PLA) and polyethylene oxide-co-poly-epsilon-caprolactone (PEO-PCL). Because both of these surfactants are uncharged diblock copolymers that rely on the mechanism of steric stabilization, we also investigate for comparison's sake the use of the small-molecule cationic surfactant cetyl trimethyl ammonium bromide (CTAB) and the much larger protein surfactant bovine serum albumin (BSA). The results presented here complement previous reports of the PFP droplet size distribution and will be useful for determining to what extent the interfacial tension value can be used to control the mean PFP droplet size. |
| Databáze: | OpenAIRE |
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