Affective disorders in the first-degree relatives of bipolar probands: results from the south island bipolar study
| Autor: | Carolyn J Doughty, Anne E S Walsh, Peter R. Joyce, J. Elisabeth Wells, Marianne Lill, Anita J. Admiraal, Robin J. Olds |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Proband medicine.medical_specialty Bipolar Disorder Bipolar I disorder lcsh:RC435-571 Suicide Attempted Bipolar II disorder Age Distribution lcsh:Psychiatry Interview Psychological mental disorders medicine Humans Registries Bipolar disorder Age of Onset Sex Distribution First-degree relatives Psychiatry Suicide attempt Depression Mood Disorders Not Otherwise Specified Age Factors Middle Aged medicine.disease Psychiatry and Mental health Clinical Psychology Mood disorders Female sense organs Psychology New Zealand |
| Zdroj: | Comprehensive Psychiatry, Vol 45, Iss 3, Pp 168-174 (2004) |
| ISSN: | 0010-440X |
| DOI: | 10.1016/j.comppsych.2004.02.005 |
| Popis: | The current study was performed to document observed rates of affective disorders in the first degree relatives of probands with bipolar I or II disorder; to determine whether bipolar II probands have an excess of bipolar II relatives; and to determine whether bipolar probands with a history of one or more suicide attempts have more relatives who have also made suicide attempts. Bipolar probands with positive family histories of affective disorder were recruited from a variety of sources for a study on the molecular genetics of bipolar disorder. Probands and relatives were interviewed with the Diagnostic Interview for Genetic Studies (DIGS) and blood was obtained for DNA extraction and genetic analyses. Among 423 first-degree adult relatives of 153 bipolar probands, 7% (29) had bipolar I disorder, 7% had bipolar II disorder, and 7% had bipolar not otherwise specified (NOS) disorder, making 21% of relatives with any bipolar disorder. A further 42% of relatives had a depressive disorder and only 38% had no affective disorder. A suicide attempt by a proband was not associated with any increase in suicide attempts by relatives. We conclude that while unipolar depressive disorders are the most common affective disorders in the first-degree relatives of bipolar probands, extension of the bipolar phenotype to include bipolar spectrum disorders results in 21% of relatives having any bipolar disorder. |
| Databáze: | OpenAIRE |
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