A triazene-based new photolabile linker in solid phase chemistry
| Autor: | Arnold Gillner, Dieter Enders, Christiaan Rijksen, Johannes Köbberling, Elke Bremus-Köbberling |
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| Přispěvatelé: | Publica |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
chemistry.chemical_classification
photochemistry Organic Chemistry Photochemistry Biochemistry Combinatorial chemistry Amino acid solid phase synthesis chemistry.chemical_compound Solid-phase synthesis chemistry Biotin Phase (matter) Drug Discovery Methanol cleavage Triazene Diethyl ether Linker triazene amino acid |
| Popis: | An extension of the T2 linker methodology by showing its applicability as a photocleavable linker is reported. Photocleavage was carried out with 355 nm UV laser irradiation (3Omega Nd-YAG) in methanol/diethyl ether and is suitable for protected amino acid derivatives, as well as simple small organic molecules including resin-bound biotin. The linker is stable under a wide range of conditions with the exception of strongly acidic media |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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