Effects of the synthetic cannabinoid 5F-AMB on anxiety and recognition memory in mice

Autor:	Katsuyuki Kaneda, Shuji Kaneko, Hitoki Sasase, Hirohito Esaki, Tong Zhang, Masaki Domoto, Akari Fukao, Satoshi Deyama, Eiichi Hinoi, Shiho Ito
Rok vydání:	2019
Předmět:	Male AM251 Cannabinoid receptor medicine.drug_class medicine.medical_treatment Prefrontal Cortex Anxiety Pharmacology Anxiolytic Open field Mice 03 medical and health sciences 0302 clinical medicine Piperidines Receptor Cannabinoid CB1 Animals Medicine Prefrontal cortex Recognition memory Memory Disorders Cannabinoids business.industry Recognition Psychology Impaired memory 030227 psychiatry Mice Inbred C57BL Pyrazoles Cannabinoid business 030217 neurology & neurosurgery medicine.drug
Zdroj:	Psychopharmacology. 236:2235-2242
ISSN:	1432-2072 0033-3158
DOI:	10.1007/s00213-019-05222-2
Popis:	N-[[1-(5-fluoropentyl)-1H-indazol-3-yl]carbonyl]-l-valine methyl ester (5F-AMB) is a synthetic cannabinoid that has been distributed recently. Although inhalation of 5F-AMB produces adverse effects, such as impaired memory and disturbed consciousness, in humans, the psychopharmacological effects of 5F-AMB in rodents have not been investigated. We first examined the effects of intraperitoneal and intracerebroventricular injections of 5F-AMB on anxiety-like behavior and locomotor activity in the open field (OF) test and recognition memory in the novel object recognition test (NOR) in C57BL/6J mice. We also examined whether a cannabinoid 1 (CB1) receptor antagonist AM251 blocks the effects of 5F-AMB. We next examined the effects of 5F-AMB infusion into the medial prefrontal cortex (mPFC), a brain region associated with anxiety and memory, on these tests. Intraperitoneal injection of 5F-AMB (0.3 mg/kg) dramatically decreased locomotor activity in the OF, and this effect was partially reversed by AM251 (3 mg/kg). Intracerebroventricular infusion of 5F-AMB (10 nmol) produced an anxiolytic effect in the OF and impaired acquisition, but not retrieval, of recognition memory in the NOR, and these effects were blocked by co-infusion of AM251 (1.8 nmol). Bilateral intra-mPFC infusion of 5F-AMB (10 pmol/side) similarly produced impaired recognition memory acquisition, but no anxiolytic effect. The results demonstrate that centrally administered 5F-AMB produces anxiolytic effect and impaired recognition memory acquisition via activation of CB1 receptors, while systemic 5F-AMB severely impaired locomotor activity. The mPFC is involved in 5F-AMB-induced impairment of recognition memory acquisition. However, other brain region(s) may contribute to the 5F-AMB-induced anxiolytic effect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e69b94f3ca924c886c75e0e4280a84f https://doi.org/10.1007/s00213-019-05222-2 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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