Chromatin remodelers: We are the drivers!!
| Autor: | Ashok Kumar Patel, Kirtika Verma, Nasir Imam, Monica Tyagi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genetics DNA Repair Transcription Genetic DNA repair Cell Biology Review Biology Chromatin Assembly and Disassembly Chromatin remodeling Chromatin Cell biology Histones 03 medical and health sciences 030104 developmental biology Histone Transcription (biology) biology.protein Nucleosome Animals Humans Disease Epigenetics ChIA-PET |
| Popis: | Chromatin is a highly dynamic structure that imparts structural organization to the genome and regulates the gene expression underneath. The decade long research in deciphering the significance of epigenetics in maintaining cellular integrity has embarked the focus on chromatin remodeling enzymes. These drivers have been categorized as readers, writers and erasers with each having significance of their own. Largely, on the basis of structure, ATP dependent chromatin remodelers have been grouped into 4 families; SWI/SNF, ISWI, IN080 and CHD. It is still unclear to what degree these enzymes are swayed by local DNA sequences when shifting a nucleosome to different positions. The ability of regulating active and repressive transcriptional state via open and close chromatin architecture has been well studied however, the significance of chromatin remodelers in regulating transcription at each step i.e. initiation, elongation and termination require further attention. The authors have highlighted the significance and role of different chromatin remodelers in transcription, DNA repair and histone variant deposition. |
| Databáze: | OpenAIRE |
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