Community-acquired pneumonia and Gram-negative bacilli in Cambodia—incidence, risk factors and clinical characteristics
| Autor: | Sirenda Vong, Laurence Borand, Blandine Rammaert, Philippe Buchy, Vantha Te, Charles Mayaud, Bertrand Guillard, Sophie Goyet, Arnaud Tarantola, Eap Tek Chheng, Malin Inghammar, Philippe Cavailler, Patrich Lorn Try |
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| Přispěvatelé: | Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Lund University [Lund], Pharmacologie des anti-infectieux (PHAR), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Takeo Provincial Hospital, Kampong Cham Provincial hospital, Kampong Cham Provincial hospital [Cambodia], GlaxoSmithKline, Glaxo Smith Kline, CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), This study was part of the Surveillance and Investigation of epidemic situations in South-East Asia (SISEA) project, which was funded by the French Agency for Development and the US Department of Human and Health Services. Malin Inghammar received grants from the Swedish Society of Medicine and Swedish governmental funds., The datasets generated and/or analysed during the current study are not publicly available but are available from the corresponding author on reasonable request. |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Gram-negative bacilli Epidemiology Drug resistance Logistic regression 0302 clinical medicine Community-acquired pneumonia Risk Factors [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Prospective Studies 030212 general & internal medicine Community acquired Prospective cohort study education.field_of_study Incidence Incidence (epidemiology) General Medicine Middle Aged Anti-Bacterial Agents 3. Good health Community-Acquired Infections Treatment Outcome Infectious Diseases Female Cambodia Adult medicine.medical_specialty Population Young Adult 03 medical and health sciences Internal medicine Pseudomonas Drug Resistance Bacterial Gram-Negative Bacteria Pneumonia Bacterial medicine Humans education Aged business.industry Public Health Environmental and Occupational Health Original Articles Pneumonia medicine.disease 030228 respiratory system Parasitology Gram-Negative Bacterial Infections business |
| Zdroj: | Transactions of The Royal Society of Tropical Medicine and Hygiene Transactions of The Royal Society of Tropical Medicine and Hygiene, Oxford University Press (OUP), 2018, 112 (2), pp.57-63. ⟨10.1093/trstmh/try022⟩ Transactions of the Royal Society of Tropical Medicine and Hygiene |
| ISSN: | 0035-9203 |
| DOI: | 10.1093/trstmh/try022⟩ |
| Popis: | International audience; Background:In Western settings, community-acquired pneumonia (CAP) due to Gram-negative bacilli (GNB) is relatively rare. Previous studies from Asia, however, indicate a higher prevalence of GNB in CAP, but data, particularly from Southeast Asia, are limited.Methods:This is a prospective observational study of 1451 patients ≥15 y of age with CAP from two hospitals in Cambodia between 2007 and 2010. The proportion of GNB was estimated. Risk factors and clinical characteristics of CAP due to GNB were assessed using logistic regression models.Results:The prevalence of GNB was 8.6% in all CAP patients and 15.8% among those with a valid respiratory sample. GNB infection was independently associated with diabetes, higher leucocyte count and CAP severity. Mortality was higher in patients with CAP due to GNB.Conclusions:We found a high proportion of GNB in a population hospitalized for CAP in Cambodia. Given the complex antimicrobial sensitivity patterns of certain GNBs and the rapid emergence of multidrug-resistant GNB, microbiological laboratory capacity should be strengthened and prospective clinical trials comparing empiric treatment algorithms according to the severity of CAP are needed |
| Databáze: | OpenAIRE |
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