Pyruvate protects against experimental stroke via an anti-inflammatory mechanism
| Autor: | Zheng Zheng, Michaël Van Hoecke, Raymond A. Swanson, Hokyou Lee, Qing Wang, Xian Nan Tang, Midori A. Yenari |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Lipopolysaccharides
Male Pyruvate Programmed cell death Lipopolysaccharide Ischemia Tetrazolium Salts Cell Count Inflammation Motor Activity Protein Serine-Threonine Kinases Biology Pharmacology Neuroprotection Article lcsh:RC321-571 Rats Sprague-Dawley chemistry.chemical_compound Pyruvic Acid medicine Animals Lactic Acid lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Microglia Body Weight Infarction Middle Cerebral Artery Ectodysplasins Cerebral ischemia medicine.disease Rats Lactic acid Stroke Disease Models Animal medicine.anatomical_structure Matrix Metalloproteinase 9 Neutrophil Infiltration Neurology chemistry Immunology Encephalitis Pyruvic acid Nervous System Diseases medicine.symptom Psychomotor Performance |
| Zdroj: | Neurobiology of Disease, Vol 36, Iss 1, Pp 223-231 (2009) |
| Popis: | Pyruvate, a key intermediate in glucose metabolism, was explored as a potential treatment in models of experimental stroke and inflammation. Pyruvate was administered to rodents after the onset of middle cerebral artery occlusion (MCAO). Since the extent of inflammation is often proportional to the size of the infarct, we also studied a group of animals given lipopolysaccharide (LPS) to cause brain inflammation without cell death. Following MCAO, pyruvate did not affect physiological parameters but significantly reduced infarct volume, improved behavioral tests and reduced numbers of neutrophils, microglial and NFkappaB activation. Animals given LPS showed increased microglial and NFkappaB activation which was almost completely abolished by pyruvate. Lactate, a major metabolite of pyruvate, was increased after pyruvate administration. However, administration of lactate itself did not have any anti-inflammatory effects. Pyruvate protects against ischemia possibly by blocking inflammation, but lactate itself does not appear to explain pyruvate's anti-inflammatory properties. |
| Databáze: | OpenAIRE |
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