Sexual dysfunction in patients with schizophrenia treated with conventional antipsychotics or risperidone
| Autor: | Bruce J. Kinon, Hong Liu-Seifert, Christopher J Tennant, Jennifer Sniadecki, Jan Volavka |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Neuropsychiatric Disease and Treatment Physiology Neurosciences. Biological psychiatry. Neuropsychiatry Quality of life hyperprolactinemia medicine In patient Psychiatry RC346-429 Biological Psychiatry Original Research risperidone Risperidone business.industry Testosterone (patch) medicine.disease Prolactin schizophrenia antipsychotics Psychiatry and Mental health Sexual dysfunction sexual dysfunction Schizophrenia Neurology. Diseases of the nervous system medicine.symptom Sexual function business medicine.drug RC321-571 |
| Zdroj: | Neuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 47-54 (2009) Neuropsychiatric Disease and Treatment |
| ISSN: | 1178-2021 1176-6328 |
| Popis: | Hong Liu-Seifert1, Bruce J Kinon1, Christopher J Tennant2, Jennifer Sniadecki1, Jan Volavka31Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA; 2CJT Biomedical Consulting, South Lake Tahoe, CA, USA; 3New York University, New York, NY, USAObjective: To better understand sexual dysfunction in patients with schizophrenia and its associations with prolactin and reproductive hormones.Methods: This was a secondary analysis of an open-label, one-day study (N = 402). The primary objective of the study was to assess the prevalence of hyperprolactinemia in patients with schizophrenia who had been treated with conventional antipsychotics or risperidone. Other atypical antipsychotics available at the time of the study were not included due to a more favorable prolactin profile.Results: The majority of patients (59% of females and 60% of males) reported impairment of sexual function. In postmenopausal females, risk of impaired sexual interest was increased by 31% for every 10 ng/ml increase in prolactin (p = 0.035). In males, lower testosterone was associated with higher prolactin (p |
| Databáze: | OpenAIRE |
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