Effects of SR141716 and WIN 55,212-2 on tolerance to ethanol in rats using the acute and rapid procedures
Autor: | Gina Struffaldi Morato, Jose Inácio Lemos, Reinaldo N. Takahashi |
---|---|
Rok vydání: | 2006 |
Předmět: |
Agonist
Male Time Factors medicine.drug_class medicine.medical_treatment Morpholines Pharmacology Motor Activity Naphthalenes chemistry.chemical_compound Piperidines Receptor Cannabinoid CB1 Cannabinoid receptor type 1 Medicine Animals Drug Interactions Rats Wistar WIN 55 212-2 Injections Intraventricular Ethanol Dose-Response Relationship Drug business.industry Antagonist Central Nervous System Depressants Drug Tolerance Endocannabinoid system Motor coordination Benzoxazines Rats Analgesics Opioid chemistry Pyrazoles Cannabinoid Rimonabant business Injections Intraperitoneal medicine.drug |
Zdroj: | Psychopharmacology. 194(2) |
ISSN: | 0033-3158 |
Popis: | Our previous findings have shown rapid cross-tolerance between ethanol and Delta(9)-tetrahydrocannabinol and that intraperitoneal (i.p.) injection of cannabinoid receptor type 1 (CB1R) antagonist SR141716 (SR) does not interfere with tolerance to either of these drugs in mice.This study investigates the effects of SR, alone or in combination with the CB receptor agonist WIN 55,212-2 (WIN), on the development of acute and rapid tolerance to the incoordinating effect of ethanol in rats.Male Wistar rats received SR, through i.p. (0.5-2.0 mg/kg) or intracerebroventricular (i.c.v.) injections (0.5-4.0 microg), alone or together with WIN (1.0 microg, i.c.v.), in combination with ethanol (2.7 g/kg, i.p.). Another group received WIN (1.0 microg, i.c.v.) in combination with ethanol (2.3 g/kg), and the rats were tested for motor coordination. Rapid tolerance was assessed 24 h later by administering ethanol to all animals and retesting them under the same dose regimen. Acute tolerance was evaluated for 75 min after ethanol (3.0 g/kg, i.p.) in animals treated with SR or WIN (i.c.v.).The reduced motor impairment on day 2 (i.e., rapid tolerance) was blocked by SR (i.p. and i.c.v.). WIN (1.0 microg, i.c.v.) facilitated rapid tolerance and also prevented the blockade of rapid tolerance by SR (1.0 microg, i.c.v.). In the acute tolerance procedure, SR did not affect the motor incoordination induced by ethanol.The results suggest that the endocannabinoid system may contribute to the development of rapid tolerance to ethanol. |
Databáze: | OpenAIRE |
Externí odkaz: |