Associations of 24-Hour Urinary Sodium and Potassium Excretion with Cardiac Biomarkers
| Autor: | Otto Bekers, Martien C. J. M. van Dongen, Marleen M.J. van Greevenbroek, Jeroen P. Kooman, Remy J.H. Martens, Anke Wesselius, Abraham A. Kroon, Simone J. P. M. Eussen, Steven J.R. Meex, Coen D.A. Stehouwer, Pieter C. Dagnelie, Ronald M.A. Henry |
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| Přispěvatelé: | Interne Geneeskunde, RS: Carim - V02 Hypertension and target organ damage, MUMC+: HVC Pieken Maastricht Studie (9), RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, MUMC+: DA CDL (5), MUMC+: DA CDL Analytisch cluster 1K (9), MUMC+: DA CDL Toegelatenen (9), RS: Carim - B01 Blood proteins & engineering, RS: CAPHRI - R5 - Optimising Patient Care, Epidemiologie, MUMC+: MA Alg Interne Geneeskunde (9), MUMC+: MA Interne Geneeskunde (3), MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Endocrinologie (9), MUMC+: MA Maag Darm Lever (9), MUMC+: MA Hematologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Nefrologie (9), MUMC+: MA Reumatologie (9), Complexe Genetica, RS: NUTRIM - R3 - Respiratory & Age-related Health, Biochemie, MUMC+: DA CDL Algemeen (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Heart disease Medicine (miscellaneous) BLOOD-PRESSURE Gastroenterology cardiovascular disease cardiac biomarkers Natriuretic Peptide Brain Prospective Studies Netherlands RISK education.field_of_study Nutrition and Dietetics biology troponin Heart Middle Aged REDUCING SALT INTAKE CARDIOVASCULAR-DISEASE POPULATION-LEVEL potassium intake potassium excretion Female medicine.symptom sodium intake medicine.medical_specialty Urinary system Population Renal function DIET Excretion Troponin T Internal medicine medicine Humans education Life Style Aged FOOD FREQUENCY QUESTIONNAIRE HYPERTENSION business.industry MORTALITY Sodium Troponin I medicine.disease Troponin Peptide Fragments INDIVIDUALS Blood pressure Cross-Sectional Studies biology.protein Albuminuria Potassium sodium excretion business natriuretic peptides Biomarkers |
| Zdroj: | Journal of Nutrition, 150(6), 1413-1424. Oxford University Press |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/nxaa080 |
| Popis: | Background: It is a matter of debate whether sodium and potassium intake are associated with heart disease. Further, the mechanisms underlying associations of sodium and potassium intake with cardiac events, if any, are not fully understood.Objectives: We examined cross-sectional associations of 24-h urinary sodium excretion (UNaE) and potassium excretion (UKE), as estimates of their intakes, with high-sensitivity cardiac troponins T (hs-cTnT) and I (hs-cTnI), and N-terminal pro-B-type natriuretic peptide (NT-proBNP), which are markers of cardiomyocyte injury and cardiac dysfunction.Methods: We included 2961 participants from the population-based Maastricht Study (mean +/- SD age 59.8 +/- 8.2 y, 51.9% men), who completed the baseline survey between November 2010 and September 2013. Associations were examined with restricted cubic spline linear regression analyses and ordinary linear regression analyses, adjusted for demographics, lifestyle, and cardiovascular disease (CVD) risk factors.Results: Median [QR] 24-h UNaE and UKE were 3.7 (2.8-4.71 g/24 h and 3.0 12.4-3.61 g/24 h, respectively. After adjustment for potential confounders, 24-h UNaE was not associated with hs-cTnT, hs-cTnI, and NT-proBNP concentrations. In contrast, after adjustment for potential confounders, lower 24-h UKE was nonlinearly associated with higher hs-cTnT and NT-proBNP. For example, as compared with the third/median quintile of 24-h UKE (range: 2.8-3.2 g/24 h), participants in the first quintile (range: 0.5-2.3 g/24 h) had 1.05 (95% CI: 0.99, 1.11) times higher hs-cTnT and 1.14 (95% CI: 1.03, 1.26) times higher NT-proBNP. Associations were similar after further adjustment for estimated glomerular filtration rate, albuminuria, blood pressure, and serum potassium.Conclusions: Twenty-four-hour UNaE was not associated with the studied cardiac biomarkers. In contrast, lower 24-h UKE was nonlinearly associated with higher hs-cTnT and NT-proBNP. This finding supports recommendations to increase potassium intake in the general population. In addition, it suggests that cardiac dysfunction and/or cardiomyocyte injury may underlie previously reported associations of lower potassium intake with CVD mortality. |
| Databáze: | OpenAIRE |
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