Interindividual Variations of Desmethylation and Hydroxylation of Amitriptyline in a Japanese Psychiatric Population
| Autor: | Yuji Ozeki, Morikazu Shibasaki, Toshifumi Noguchi, Toshiyuki Someya, Sachiyo Morita, Kazutaka Shimoda, Saburo Takahashi |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Drug medicine.medical_specialty Amitriptyline Hydrochloride Amitriptyline media_common.quotation_subject Population Nortriptyline Pharmacology Hydroxylation Methylation chemistry.chemical_compound Japan medicine Humans Distribution (pharmacology) Pharmacology (medical) Psychiatry education Biotransformation Aged media_common education.field_of_study Dose-Response Relationship Drug Mental Disorders Middle Aged Psychiatry and Mental health Dose–response relationship chemistry Female medicine.drug |
| Zdroj: | Journal of Clinical Psychopharmacology. 15:175-181 |
| ISSN: | 0271-0749 |
| DOI: | 10.1097/00004714-199506000-00005 |
| Popis: | We measured the concentrations in plasma of amitriptyline and its metabolites, nortriptyline and geometric isomers of 10-hydroxynortriptyline and 10-hydroxyamitriptyline, in 73 Japanese psychiatric patients receiving amitriptyline hydrochloride (Tryptanol; Banyu Pharmaceutical Co. Ltd., Tokyo, Japan) by high-performance liquid chromatography. Although there were large interindividual variations of total drug concentrations and concentrations of parent or intermediate metabolic compounds in plasma, significant positive correlations were observed between these drug concentrations and daily doses of amitriptyline hydrochloride (milligrams per kilogram of body weight). The metabolic ratios for both hydroxylation and desmethylation varied substantially with approximately 8- to 19-fold interindividual variations. Frequency distribution histograms and probit analyses of these parameters identified neither definite poor hydroxylators nor poor desmethylators of amitriptyline. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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