Melanocortin 3 receptor-expressing neurons in the ventromedial hypothalamus promote glucose disposal
| Autor: | James M. Dell’Orco, Amy K. Sutton, David P. Olson, Ian E. Gonzalez, Paulette B. Goforth, Martin G. Myers, Hongjuan Pei |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Pro-Opiomelanocortin Hypothalamus 030209 endocrinology & metabolism Biology Hypoglycemia 03 medical and health sciences Mice 0302 clinical medicine Proopiomelanocortin Arcuate nucleus medicine Premovement neuronal activity Animals Neurons Multidisciplinary ventromedial nucleus Biological Sciences Synaptic Potentials medicine.disease Melanocortin 3 receptor Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Glucose nervous system Hyperglycemia Excitatory postsynaptic potential biology.protein Neuron Neuroscience Receptor Melanocortin Type 3 |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | The ventromedial hypothalamus (VMH) is a critical neural node that senses blood glucose and promotes glucose utilization or mobilization during hypoglycemia. The VMH neurons that control these distinct physiologic processes are largely unknown. Here, we show that melanocortin 3 receptor ( Mc3R )-expressing VMH neurons (VMH MC3R ) sense glucose changes both directly and indirectly via altered excitatory input. We identify presynaptic nodes that potentially regulate VMH MC3R neuronal activity, including inputs from proopiomelanocortin (POMC)-producing neurons in the arcuate nucleus. We find that VMH MC3R neuron activation blunts, and their silencing enhances glucose excursion following a glucose load. Overall, these findings demonstrate that VMH MC3R neurons are a glucose-responsive hypothalamic subpopulation that promotes glucose disposal upon activation; this highlights a potential site for targeting dysregulated glycemia. |
| Databáze: | OpenAIRE |
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