Correlation between molecular and clinical events in the evolution of chronic myelocytic leukemia to blast crisis

Autor:	A Foti, S. L. Allen, P. Schulman, M. W. Schuster, M. Bar-Eli, HG Ahuja, Martin J. Cline, Prasad Koduru
Rok vydání:	1991
Předmět:	Myeloid business.industry Point mutation Immunology Disease Cell Biology Hematology medicine.disease Philadelphia chromosome Biochemistry Leukemia medicine.anatomical_structure Concomitant hemic and lymphatic diseases medicine Myelocytic leukemia business Gene
Zdroj:	Scopus-Elsevier
ISSN:	1528-0020 0006-4971
DOI:	10.1182/blood.v77.11.2441.bloodjournal77112441
Popis:	A patient with typical Philadelphia chromosome (Ph1)-positive chronic myelocytic leukemia (CML) was studied during sequential phases of disease: (1) initial chronic phase; (2) myeloid blast crisis; (3) second chronic phase; and (4) accelerated disease. A point mutation in the coding sequence of the p53 gene first appeared concomitantly with the blast crisis and then disappeared with the re-establishment of a second chronic phase. The chromosomal concomitant of the molecular alteration was a deletion of 17p. These observations suggest that abnormalities of the p53 anti-oncogene are temporally related to the clinical progression of some cases of CML and are probably responsible for the development of blast crisis in these cases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e61f9ae9c30d0cb1923686bfdab0f6b https://doi.org/10.1182/blood.v77.11.2441.bloodjournal77112441 Zobrazit plný text záznamu