Outcome and management in neonatal thrombocytopenia due to maternal idiopathic thrombocytopenic purpura

Autor:	A. van Kampen, Enrico Lopriore, N. M. van der Lugt, Frans J. Walther, Anneke Brand
Rok vydání:	2013
Předmět:	Adult Blood Platelets Pediatrics medicine.medical_specialty Neonatal Thrombocytopenia Young Adult neonatal thrombocytopenia Pregnancy Recurrence Risk Factors Prednisone intravenous immunoglobulin hemic and lymphatic diseases medicine Humans Platelet intracranial haemorrhage Purpura Thrombocytopenic Idiopathic Platelet Count business.industry Pregnancy Complications Hematologic Infant Newborn Immunoglobulins Intravenous Hematology General Medicine maternal Idiopathic thrombocytopenic purpura medicine.disease Thrombocytopenic purpura Pathophysiology Surgery Thrombocytopenia Neonatal Alloimmune Treatment Outcome Platelet transfusion Cohort prednisone platelet transfusion Female business medicine.drug
Zdroj:	Vox Sanguinis, 105(3), 236-243
ISSN:	0042-9007
DOI:	10.1111/vox.12036
Popis:	Background and Objectives Pregnant women with Idiopathic thrombocytopenic purpura (ITP) can deliver neonates with severe thrombocytopenia. Clear evidence declaring the pathophysiological cause of this neonatal thrombocytopenia is lacking, as antiplatelet antibodies are not always detectable in maternal serum. Severe neonatal thrombocytopenia below 50 × 109/l is reported in 8–13% of the neonates from mothers with ITP and intracranial haemorrhage (ICH) in 0–2·9%. Evidence about the optimal postnatal treatment is scarce. Our objective was to evaluate the outcome and management in neonates with passive ITP. Materials and Methods All neonates from mothers with ITP born between 1980 and 2011 were included. Platelet counts during the first 10 days, presence of ICH and postnatal treatment were recorded. Maternal characteristics were analysed as possible risk factors for severe neonatal thrombocytopenia. Results Sixty-seven neonates were included. Severe thrombocytopenia (
Databáze:	OpenAIRE
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