Dental anomalies in pediatric patients with familial adenomatous polyposis
| Autor: | Karen B. Williams, Brenda S. Bohaty, Lynn Roosa Friesen, Craig A. Friesen, Seth Septer, Robin Onikul, Vandana Kumar, Thomas M. Attard |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Panoramic radiograph Adolescent Colorectal cancer Adenomatous polyposis coli Adenomatous Polyposis Coli Protein Gene mutation Familial adenomatous polyposis 03 medical and health sciences 0302 clinical medicine stomatognathic system Radiography Panoramic Epidemiology Prevalence Genetics medicine Humans Child Genetics (clinical) Retrospective Studies Dental anomalies Dentofacial Deformities biology business.industry Medical record Osteoma 030206 dentistry medicine.disease Dermatology Mandibular Neoplasms stomatognathic diseases Adenomatous Polyposis Coli Jaw Oncology Case-Control Studies 030220 oncology & carcinogenesis Mutation biology.protein Female business Osteosclerosis |
| Zdroj: | Familial Cancer. 17:229-234 |
| ISSN: | 1573-7292 1389-9600 |
| DOI: | 10.1007/s10689-017-0035-5 |
| Popis: | Familial adenomatous polyposis patients often present with non-malignant extra-intestinal manifestations which include dental anomalies that may be evident prior to the appearance of the colonic adenomas. The aims of this study were to describe the prevalence and type of dental anomalies and the relationships between gene mutations and dental anomalies in these patients. Twenty-two pediatric familial adenomatous polyposis patients and 46 controls, who were age and gender matched participated. Familial adenomatous polyposis patient's had a dental examination with panoramic radiograph and medical record review for age at diagnosis, the presence of the adenomatous polyposis coli gene mutation, and determination of other extra-intestinal manifestations on the body. The control group was identified from a retrospective chart review and selected if there was a current panoramic radiograph. The only significant difference between familial adenomatous polyposis patients and controls were the presence of jaw osteomas and sclerosis (p = .0001). Patients with a mutation in, or upstream of codon 1309 had a higher frequency of osteomas (77.8%) and jaw-bone sclerosis (44.4%), and 77% of these had at least one dental anomaly. This preliminary study showed an association between a genetic variant at, or upstream of codon 1309, and radiographic dental anomalies. |
| Databáze: | OpenAIRE |
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