Tumor radiation response enhancement by acoustical stimulation of the vasculature
| Autor: | Shun Wong, Anoja Giles, Emily H. M. Wong, Azza Al Mahrouki, Peter N. Burns, Christina Kim, William T. Tran, Justin Lee, Melissa Furukawa, Raffi Karshafian, Gregory J. Czarnota, Amanda Caissie |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology medicine.medical_specialty Urology Transplantation Heterologous Apoptosis Stimulation Mice SCID Biology Ceramides Radiation Tolerance Mice chemistry.chemical_compound Prostate cancer Sphingosine In vivo Cell Line Tumor medicine Animals Humans Combined Modality Therapy Ultrasonography Analysis of Variance Microbubbles Multidisciplinary business.industry Histological Techniques Ultrasound Prostatic Neoplasms Dose-Response Relationship Radiation medicine.disease Acoustic Stimulation Microscopy Fluorescence PNAS Plus chemistry Cancer research Endothelium Vascular Lysophospholipids business Radiation response Biomedical engineering |
| Zdroj: | Proceedings of the National Academy of Sciences. 109 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1200053109 |
| Popis: | We have discovered that ultrasound-mediated microbubble vascular disruption can enhance tumor responses to radiation in vivo. We demonstrate this effect using a human PC3 prostate cancer xenograft model. Results indicate a synergistic effect in vivo with combined single treatments of ultrasound-stimulated microbubble vascular perturbation and radiation inducing an over 10-fold greater cell kill with combined treatments. We further demonstrate with experiments in vivo that induction of ceramide-related endothelial cell apoptosis, leading to vascular disruption, is a causative mechanism. In vivo experiments with ultrasound and bubbles permit radiation doses to be decreased significantly for comparable effect. We envisage this unique combined ultrasound-based vascular perturbation and radiation treatment method being used to enhance the effects of radiation in a tumor, leading to greater tumor eradication. |
| Databáze: | OpenAIRE |
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