Corticotropin-releasing hormone (CRH) receptors in the mesenteric small arteries of rats resemble the (2)-subtype
| Autor: | Michael Bienert, Klaus Fechner, Elvira Rohde, Carl Denef, Jens Furkert, Michael Beyermann, Regina M. Richter, Michael J. Mulvany, Hartmut Berger |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Pituitary gland Vascular smooth muscle Corticotropin-Releasing Hormone Sauvagine Biology Peptide hormone Binding Competitive Receptors Corticotropin-Releasing Hormone Biochemistry Radioligand Assay Corticotropin-releasing hormone Adrenocorticotropic Hormone Internal medicine medicine Animals Rats Wistar Receptor Mesenteric arteries Pharmacology Mesenteric Arteries Rats medicine.anatomical_structure Endocrinology hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Biochemical Pharmacology. 52:829-833 |
| ISSN: | 0006-2952 |
| DOI: | 10.1016/0006-2952(96)00300-0 |
| Popis: | The potencies of the corticotropin-releasing hormone (CRH) agonistic peptides oCRH, h/rCRH, frog sauvagine, and carp urotensin I and of the antagonistic peptide α-helical CRH9-41 were compared in 3 different in vitro assays: (a) receptor binding to rat brain membranes; (b) release of ACTH/β-endorphin from rat pituitary cells; and (c) relaxation of rat mesenteric small arteries. From their potency profiles, especially from the high potency of sauvagine relative to CRH in the relaxation assay, it is concluded that the receptors mediating the hypotensive action of systemic CRH in vascular smooth muscle are different from those in the pituitary and brain, and may be identical or very similar to the recently cloned new CRH receptor type 2. |
| Databáze: | OpenAIRE |
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