Keloidectomy with core fillet flap and intralesional verapamil injection for recurrent earlobe keloids
| Autor: | Moheiddin Alghobary, Mohammed Fawzy El-Kamel, Mohamed Khaled Selim |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Dermatology Injections Intralesional 030207 dermatology & venereal diseases 03 medical and health sciences Young Adult 0302 clinical medicine Keloid Medicine Humans Prospective Studies Fillet (mechanics) Prospective cohort study Earlobe Verapamil Injection business.industry Extracellular matrix molecules Middle Aged medicine.disease Calcium Channel Blockers Response to treatment Surgery Infectious Diseases medicine.anatomical_structure Verapamil 030220 oncology & carcinogenesis Female business medicine.drug Ear Auricle Follow-Up Studies |
| Zdroj: | Indian journal of dermatology, venereology and leprology. 82(6) |
| ISSN: | 0973-3922 |
| Popis: | Background: Earlobe keloids are usually recalcitrant to treatment and have a high rate of recurrence. Verapamil is a calcium channel antagonist that has been shown to inhibit the synthesis/secretion of extracellular matrix molecules and increase collagenase. Objectives: This prospective study was designed to evaluate the results of treatment of recurrent earlobe keloids using keloidectomy with core fillet flap and intralesional verapamil injection. Methods: Nineteen keloids in 16 patients were treated using this technique with intralesional verapamil injection given intraoperatively, then every 2 weeks for 3 months, with postoperative follow-up for 18 months. Results: Fourteen patients completed the study. Ten patients (71.4%) showed response to treatment. Four (28.6%) cases showed recurrence, two (14.2%) at the wound bed and another two (14. 2%) at the incision line. Eighty percent of responders were highly satisfied with their treatment. Conclusion: Keloidectomy with core fillet flap and intralesional verapamil injection is a reliable and cost-effective method in the treatment of recurrent earlobe keloids with a low rate of recurrence and high patient satisfaction. |
| Databáze: | OpenAIRE |
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