Zfh1, a somatic motor neuron transcription factor, regulates axon exit from the CNS
| Autor: | Joanne P. Odden, Michael J. Layden, Alain Garces, Chris Q. Doe, Aloisia Schmid, Stefan Thor |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Islet
Interneuron Somatic cell Biology 03 medical and health sciences 0302 clinical medicine Transcription (biology) Interneurons medicine Animals Drosophila Proteins Axon outgrowth Axon Transcription factor Molecular Biology 030304 developmental biology Motor Neurons 0303 health sciences Kheper Axon guidance lim3 Brain Anatomy Cell Biology Motor neuron Embryonic stem cell Axons Motoneuron mnr2 Neuronal identity DNA-Binding Proteins Repressor Proteins medicine.anatomical_structure nervous system hb9 zfh1 Drosophila unc-5 Axon projection Neuroscience 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Developmental Biology. 291(2):253-263 |
| ISSN: | 0012-1606 |
| DOI: | 10.1016/j.ydbio.2005.12.009 |
| Popis: | Motor neurons are defined by their axon projections, which exit the CNS to innervate somatic or visceral musculature, yet remarkably little is known about how motor axons are programmed to exit the CNS. Here, we describe the role of the Drosophila Zfh1 transcription factor in promoting axon exit from the CNS. Zfh1 is detected in all embryonic somatic motor neurons, glia associated with the CNS surface and motor axons, and one identified interneuron. In zfh1 mutants, ventral projecting motor axons often stall at the edge of the CNS, failing to enter the muscle field, despite having normal motor neuron identity. Conversely, ectopic Zfh1 induces a subset of interneurons—all normally expressing two or more “ventral motor neuron transcription factors” (e.g. Islet, Hb9, Nkx6, Lim3)—to project laterally and exit the CNS. We conclude that Zfh1 is required for ventral motor axon exit from the CNS. |
| Databáze: | OpenAIRE |
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