Lifestyle and family history influence cancer prognosis in Brazilian individuals
| Autor: | Aurigena Antunes de Araújo, Hugo Gonçalo Guedes, George A. Lira, Francisco J. Cavalcante, Raimundo Fernandes de Araújo, Carlos César de Oliveira Ramos, Marília A. Cardoso, Ana Lucia M. Araújo |
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| Jazyk: | portugalština |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Alcohol Drinking Survival Colorectal cancer Pathology and Forensic Medicine Risk Factors Internal medicine medicine Humans Risk factor Family history Stage (cooking) Life Style Mass screening Aged Neoplasm Staging Retrospective Studies Public health business.industry Smoking Cancer Retrospective cohort study Cell Biology Middle Aged medicine.disease Prognosis Neoplasm by site Surgery Female business Colorectal Neoplasms Brazil |
| Zdroj: | Repositório Institucional da UFRN Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
| Popis: | The aim of this research was to study prognostic parameters of CRC by analyzing clinical and pathological variables associated with cancer patients at a northeastern Brazilian Hospital. This was a retrospective study evaluating CRC-diagnosed patients across a 10-year period (1995–2005) at Dr. Luiz Antônio Hospital in Natal, RN, Brazil. Data were collected from patients’ medical files. A total of 358 patients were included over the 10-year period. The average age at diagnosis was 58.8 years (S.D. = 15.26), 48.3% of the patients were males and 51.7% were females. Alcohol consumption significantly increased the chance of dying (p < 0.023) from colorectal cancer; this increased risk of death was approximately 71%, compared to 52.2% of the non-alcoholics. In addition, tobacco increased the chance of developing high TNM stage tumors (level III, IV; p < 0.001). Another risk factor for increased mortality was a family history for colorectal cancer (p < 0.002). Our analysis found that patients with an unhealthy lifestyle and/or family history of colorectal cancer were more likely to develop advanced stage colorectal cancer and to have a poor disease prognosis compared to patients with healthy lifestyle and/or sporadic colorectal cancer. These data suggest that a mass screening program should be implemented in northeastern Brazil in order to better prevent and treat colorectal cancer. |
| Databáze: | OpenAIRE |
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