Infection with Toxoplasma gondii does not Alter TNFα and IL-6 Secretion by A human Astrocytoma Cell Line
| Autor: | A. Meunier, J. Ricard, J P Vuillez, Pierre Ambroise-Thomas, Hervé Pelloux, M.-F. Nissou, J.-C. Renversez |
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| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
Lipopolysaccharide
biology medicine.medical_treatment Immunology Toxoplasma gondii Cell Biology biology.organism_classification Virology Molecular biology chemistry.chemical_compound Cytokine chemistry Cell culture biology.protein medicine lcsh:Pathology Tumor necrosis factor alpha Secretion Interferon gamma Interleukin 6 Research Article medicine.drug lcsh:RB1-214 |
| Zdroj: | Mediators of Inflammation, Vol 3, Iss 4, Pp 291-295 (1994) Mediators of Inflammation |
| ISSN: | 1466-1861 0962-9351 |
| Popis: | The secretion of tumour necrosis factor-α (TNFα), interleukin-1α (IL-α) and interleukin-6 (IL-6) by a human astrocytoma cell fine was studied 1 h, 3 h, 6 h and 24 h after infection with tachyzoites from threeToxoplasma gondiistrains (virulent, RH; cystogentc, 76K and Prugniaud strains). The astrocytoma cell fine constitutively secreted TNFα and IL-6, but no IL-1α. A positive control was obtained by stimulation with phorbol esters inducing a significant increase (p<0.05) in TNFα and IL- 6 secretion but not in IL-1α, while lipopolysaccharide (alone and after priming), interferon gamma, ionophore A 23187 and sera positive toT. gondiidid not induce any increase in cytokine levels. None of the tachyzoites, whatever their virulence, induced a significant increase in cytokine production at any time in the study. Tachyzoites did not inhibit the secretion induced by phorbol esters. |
| Databáze: | OpenAIRE |
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