Estrogen receptor subtype-specific effects on markers of bone homeostasis
| Autor: | Patrick Diel, B. Schleipen, T. Hertrampf, M. Velders, U. Laudenbach, Karl Heinrich Fritzemeier |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Agonist
medicine.medical_specialty Bone density medicine.drug_class Ovariectomy Estrogen receptor 030209 endocrinology & metabolism Biochemistry Bone and Bones Random Allocation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Bone Density Internal medicine polycyclic compounds medicine Animals Estrogen Receptor beta Homeostasis Osteopontin Molecular Biology ComputingMilieux_MISCELLANEOUS 030304 developmental biology Bone mineral 0303 health sciences Pyridinoline Estradiol Molecular Structure biology Chemistry Uterus Estrogen Receptor alpha Life Sciences Organ Size Rats Ovariectomized rat Osteocalcin biology.protein Female Biomarkers hormones hormone substitutes and hormone antagonists |
| Zdroj: | Molecular and Cellular Endocrinology Molecular and Cellular Endocrinology, Elsevier, 2008, 291 (1-2), pp.104. ⟨10.1016/j.mce.2008.03.003⟩ |
| ISSN: | 0303-7207 |
| DOI: | 10.1016/j.mce.2008.03.003 |
| Popis: | To further elucidate the processes involved in the physiology of bone-protection by estrogens, ovariectomized (OVX) rats were treated subcutaneously with 17beta-estradiol (E(2)), the ERalpha-specific agonist (16alpha-LE2) and the ERbeta-specific agonist (8beta-VE2). OVX and intact animals served as controls. Biomarkers of bone-formation (osteocalcin (OC), osteopontin (OPN)) and bone-resorption (telopeptides of collagen type I (CTx), pyridinoline cross-links (Pyd)) were quantified. Bone mineral density was measured by computed tomography. OVX-induced bone loss could be antagonized by subcutaneous administration of 17beta-estradiol and 16alpha-LE2. Serum levels of CTx, OC and OPN were significantly elevated in OVX compared to intact animals and reduced by 17beta-estradiol and 16alpha-LE2. Treatment of OVX rats with 8beta-VE2 did not affect bone mineral density (BMD) or bone-marker serum levels. Taken together, the complex expression pattern of bone-markers in OVX rats following subcutaneous administration of ER subtype-specific agonists indicates that 17beta-estradiol exerts its bone-protective effects by modulating the activity of osteoclasts and osteoblasts via ERalpha. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect