Glutathione-Sensitive Nanoglue Platform with Effective Nucleic Acids Gluing onto Liposomes for Photo-Gene Therapy

Autor: Yue Yu, Zhenfeng Wang, Sichen Wu, Chunmeng Zhu, Xianshe Meng, Chao Li, Sheng Cheng, Wei Tao, Feng Wang
Rok vydání: 2022
Předmět:
Zdroj: ACS applied materialsinterfaces. 14(22)
ISSN: 1944-8252
Popis: Liposomal spherical nucleic acids possess a high density of nucleic acids, e.g., DNA, on a liposomal core. There are two approaches to conjugate DNA onto the zwitterionic liposomes, i.e., covalent and noncovalent conjugation, otherwise using cationic liposomes. However, complex and expensive DNA chemical modification methods need to seek a novel and easy-operating approach to decorating DNA onto liposomes. Inspired by the nanoparticle solution as nanoglues for gels and biological tissues, we use MnO
Databáze: OpenAIRE