Fatty acid composition of brown adipose tissue in genetically heat-tolerant FOK rats
| Autor: | Tomie Ohno, Fujiya Furuyama, Akihiro Kuroshima |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Atmospheric Science medicine.medical_specialty Hot Temperature Meteorological Concepts Health Toxicology and Mutagenesis Linoleic acid Phospholipid chemistry.chemical_compound Adipose Tissue Brown Internal medicine Brown adipose tissue medicine Animals Rats Wistar Phospholipids chemistry.chemical_classification Ecology Fatty Acids Fatty acid Rats Inbred Strains Rats Endocrinology medicine.anatomical_structure chemistry Biochemistry Docosahexaenoic acid Arachidonic acid Thermogenesis Body Temperature Regulation Polyunsaturated fatty acid |
| Zdroj: | International Journal of Biometeorology. 45:41-44 |
| ISSN: | 1432-1254 0020-7128 |
| DOI: | 10.1007/s004840000082 |
| Popis: | The phospholipid fatty acid composition of brown adipose tissue (BAT) was examined in inbred heat-tolerant FOK rats and compared with that in conventional Wistar rats not previously exposed to heat. The FOK rats showed higher unsaturation states, as indicated by higher levels of polyunsaturated fatty acids and a higher unsaturation index and polyunsaturated fatty acids/saturated fatty acids ratio. This higher level of unsaturation was characterized by the higher amount of polyunsaturated fatty acids such as linoleic acid, arachidonic acid and docosahexaenoic acid. It may be concluded that the increased docosahexaenoic acid level in BAT phospholipids brings about the hyperplasia of BAT, causing an enhancement of its in vivo thermogernic activity as well as the systemic non-shivering thermogenesis observed in heat-tolerant FOK rats. |
| Databáze: | OpenAIRE |
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