Contrast-enhanced magnetic resonance imaging reveals early decrease of transmural extent of reperfused acute myocardial infarction
| Autor: | Hugo A. Katus, Christian Kulke, Henning Steen, Evangelos Giannitsis, Constanze Merten |
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| Rok vydání: | 2008 |
| Předmět: |
Gadolinium DTPA
Male medicine.medical_specialty Time Factors Myocardial Infarction Contrast Media Coronary artery disease Internal medicine medicine Myocardial Revascularization Humans In patient cardiovascular diseases Myocardial infarction skin and connective tissue diseases Contrast-enhanced Magnetic Resonance Imaging Aged medicine.diagnostic_test business.industry Transmural infarct Magnetic resonance imaging General Medicine Middle Aged Infarct size medicine.disease Prognosis Magnetic Resonance Imaging Cardiology Female Imaging technique Cardiology and Cardiovascular Medicine business |
| Zdroj: | Clinical research in cardiology : official journal of the German Cardiac Society. 97(12) |
| ISSN: | 1861-0692 |
| Popis: | In patients with myocardial infarction infarct size and transmural extent are of high prognostic value for clinical outcome and recovery of contractile function of the affected myocardium either spontaneously or after revascularisation. Delayed contrast-enhancement magnetic resonance imaging (DCE-MRI) is a non-invasive imaging technique of high accuracy for determination of myocardial infarct size and transmural extent. As decisions whether revascularisation procedures are promising in patients with coronary artery disease are increasingly based on the transmural infarct extent assessed by DCE-MRI we sought to examine whether the timing of MRI after acute myocardial infarction would influence the transmural extent. We performed DCE-imaging on a clinical 1.5 T scanner in patients at day-1 and day-7 after reperfused STEMI. We assessed the total number of segments displaying DCE as well as differentiated by the transmural infarct extent. The total number of affected segments as well as the number of segments with only subendocardial DCE did not change between day-1 and day-7. In contrast, we observed a significant decrease of the number of segments with DCE of > or =75% transmurality and a significant increase of segments with DCE grade III (51%-75% transmurality). We conclude that the transmural infarct extent is not stable over the first days after STEMI which should be taken into account when assessing viability in clinical and research settings. |
| Databáze: | OpenAIRE |
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