Application of Fenton, photo-Fenton, solar photo-Fenton, and UV/H2O2 to degradation of the antineoplastic agent mitoxantrone and toxicological evaluation
| Autor: | Rodrigo Pereira Cavalcante, Sílvio C. de Oliveira, Antonio Marcos Jacques Barbosa, Marly Eiko Osugi, Lucas da Rocha Sandim, Valdir Souza Ferreira, Matildes Blanco, Amilcar Machulek, Danielle Bogo, Maria de Fatima Cepa Matos |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
inorganic chemicals
Ultraviolet Rays Health Toxicology and Mutagenesis Potassium Iron chemistry.chemical_element Antineoplastic Agents Water Purification chemistry.chemical_compound Mice Spectrophotometry medicine Environmental Chemistry Animals Cytotoxicity Hydrogen peroxide Voltammetry Mitoxantrone Chromatography Photolysis medicine.diagnostic_test Chemistry General Medicine Hydrogen Peroxide Pollution NIH 3T3 Cells Sunlight Titration Stoichiometry Water Pollutants Chemical medicine.drug Nuclear chemistry |
| Zdroj: | Environmental science and pollution research international. 20(4) |
| ISSN: | 1614-7499 |
| Popis: | In the present study, selected advanced oxidation processes (AOPs)-namely, photo-Fenton (with Fe(2+), Fe(3+), and potassium ferrioxalate-FeOx-as iron sources), solar photo-Fenton, Fenton, and UV/H2O2-were investigated for degradation of the antineoplastic drug mitoxantrone (MTX), frequently used to treat metastatic breast cancer, skin cancer, and acute leukemia. The results showed that photo-Fenton processes employing Fe(III) and FeOx and the UV/H2O2 process were most efficient for mineralizing MTX, with 77, 82, and 90% of total organic carbon removal, respectively. MTX probably forms a complex with Fe(III), as demonstrated by voltammetric and spectrophotometric measurements. Spectrophotometric titrations suggested that the complex has a 2:1 Fe(3+):MTX stoichiometric ratio and a complexation constant (K) of 1.47 × 10(4) M(-1), indicating high MTX affinity for Fe(3+). Complexation partially inhibits the involvement of iron ions and hence the degradation of MTX during photo-Fenton. The UV/H2O2 process is usually slower than the photo-Fenton process, but, in this study, the UV/H2O2 process proved to be more efficient due to complexing of MTX with Fe(III). The drug exhibited no cytotoxicity against NIH/3T3 mouse embryonic fibroblast cells when oxidized by UV/H2O2 or by UV/H2O2/FeOx at the concentrations tested. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink