The copper complex of captopril is not a superoxide dismutase mimic. Artefacts in DMPO spin trapping
| Autor: | Grzegorz Bartosz, Małgorzata Bartosz, Józef Kędziora |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Captopril
chemistry.chemical_element Photochemistry Biochemistry Antioxidants Superoxide dismutase Cyclic N-Oxides chemistry.chemical_compound medicine cardiovascular diseases Autoxidation biology Spin trapping Chemistry Superoxide Superoxide Dismutase Nitroblue Tetrazolium General Medicine Free Radical Scavengers Copper Pyrogallol biology.protein Nitro Spin Labels Artifacts Spin Trapping hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology medicine.drug |
| Zdroj: | Free radical research. 24(5) |
| ISSN: | 1071-5762 |
| Popis: | The effect of captopril and of its copper complex on several superoxide-dependent reactions used to detect and assay superoxide dismutase activity was studied, including pyrogallol and hematoxylin autoxidation and Nitro Blue Tetrazolium reduction. ln none of these systems were superoxide dismutase-like properties of captopril/Cu apparent. Captopril/Cu decreased the yield of DMPO-OH adducts generated by KO2 but this effect may be due to the acceleration of the decay of the adduct by captopril/Cu. |
| Databáze: | OpenAIRE |
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