The Effect of Acute Glutamine Supplementation on Markers of Inflammation and Fatigue During Consecutive Days of Simulated Wildland Firefighting
| Autor: | Roberto Nava, Micah Zuhl, Kelli E. King, Kelsey Bourbeau, Terence A. Moriarty, Fabiano T. Amorim, Christine M. Mermier, James J. McCormick, Anna M. Welch |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Glutamine Alpha (ethology) Inflammation Fatty Acid-Binding Proteins medicine.disease_cause Placebo Gastroenterology law.invention Young Adult Oxygen Consumption Double-Blind Method Randomized controlled trial law Internal medicine medicine Humans Fatigue business.industry Public Health Environmental and Occupational Health Hsp70 IκBα Firefighters Dietary Supplements Female medicine.symptom business Biomarkers Oxidative stress |
| Zdroj: | Journal of Occupational & Environmental Medicine. 61:e33-e42 |
| ISSN: | 1076-2752 |
| DOI: | 10.1097/jom.0000000000001507 |
| Popis: | Objective To examine the effect of oral glutamine supplementation on inflammation and fatigue during and after simulated wildland firefighting (WLFF) tasks in hot conditions over 2 consecutive days. Methods Eleven men and women ingested a glutamine supplement or a placebo before and after simulated wildland firefighting in an environmental chamber (38 °C, 35% relative humidity). Subjective fatigue, markers of inflammation, and cellular stress were measured pre, post and 4 hours post-exercise on both days. Results Gastrointestinal damage, subjective fatigue, and ratings of perceived exertion were lower after glutamine supplementation compared with placebo. Heat shock protein 70 (HSP70) and nuclear factor kappa-inhibitor alpha (IκBα) levels were higher on both days of the glutamine trial compared with placebo. Conclusions Glutamine supplementation may improve recovery after fire suppression in WLFFs. This may result from the upregulation of HSP70 which inhibits inflammation and protects against gastrointestinal (GI) barrier damage. |
| Databáze: | OpenAIRE |
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