Ischemia-Modified Albumin Expression: Is there a Difference between Male and Female Subjects?
| Autor: | Alina Beraudi, Aldo Toni, Giovanni Bracci, Simona Catalani, Dalila De Pasquale, Marilina Amabile, Susanna Stea |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 030213 general clinical medicine medicine.medical_specialty Iron Population Serum albumin chemistry.chemical_element Serum Albumin Human General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Sex Factors 0302 clinical medicine Internal medicine medicine Humans education Serum Albumin chemistry.chemical_classification education.field_of_study medicine.diagnostic_test biology business.industry Transferrin Albumin Case-control study Cobalt Middle Aged Ferritin Endocrinology chemistry Case-Control Studies Ferritins Serum iron biology.protein Female business Biomarkers |
| Zdroj: | Clinical Laboratory. 65 |
| ISSN: | 1433-6510 |
| DOI: | 10.7754/clin.lab.2018.180811 |
| Popis: | BACKGROUND Ischemia-modified albumin (IMA) derives from naive albumin, modified in the binding region of bivalent ions, as cobalt and iron. The cobalt, released from some types of hip prosthesis seems to be metabolized differently in males and females but the iron ion is more prevalent than cobalt and is detectable in the healthy population. Our aim was to verify if there are any gender- and age-related differences in IMA concentrations and if IMA correlates with cobalt and iron-related proteins. METHODS IMA, albumin, iron, ferritin, transferrin, and cobalt were measured in 50 men and 50 women divided into two age/fertility-homogeneous groups. RESULTS Men < 45-years-old showed a statistically significant lower IMA concentration than men ≥ 45 and fertile and menopausal women. Considering all the population studied, IMA does not seem to be correlated with age and is distributed differently by gender; also, Co distribution was different between males and females. CONCLUSIONS IMA did not correlate with cobalt, iron, ferritin, and transferrin in any group, except for fertile women where IMA presented a statistically significant correlation with serum iron values. Minor expression of IMA in young males together with the results obtained on serum iron in fertile females, could explain the higher accumulation of circulating Co in women compared to men and their different cobalt metabolism. |
| Databáze: | OpenAIRE |
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