The Barnes Maze Task Reveals Specific Impairment of Spatial Learning Strategy in the Intrahippocampal Kainic Acid Model for Temporal Lobe Epilepsy
| Autor: | Yana Van Den Herrewegen, Giulia Albertini, Lissa Denewet, Ann Van Eeckhaut, Ilse Julia Smolders, An Buckinx, Dimitri De Bundel |
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| Přispěvatelé: | Pharmaceutical and Pharmacological Sciences, Faculty of Medicine and Pharmacy, Experimental Pharmacology, Alliance for Modulation in Epilepsy |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Neurology Memory Dysfunction The Barnes maze Spatial Learning Morris water navigation task Context (language use) Hippocampus Biochemistry Temporal lobe Intrahippocampal post-status epilepticus Kainic Acid model 03 medical and health sciences Epilepsy Cellular and Molecular Neuroscience 0302 clinical medicine medicine Animals Spatial learning and memory Search strategy Maze Learning Spatial Memory Kainic Acid Behavior Animal Cognition General Medicine temporal lobe epilepsy medicine.disease Barnes maze Mice Inbred C57BL Disease Models Animal 030104 developmental biology Epilepsy Temporal Lobe Space Perception Psychology Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes |
| Popis: | Temporal lobe epilepsy (TLE) is an acquired form of focal epilepsy, in which patients not only suffer from unprovoked, devastating seizures, but also from severe comorbidities, such as cognitive dysfunction. Correspondingly, several animal models of TLE exhibit memory dysfunction, especially spatial memory. The Morris water maze test is the most commonly used test for assessing spatial learning and memory in rodents. However, high stress and poor swimming abilities are common confounders and may contribute to misinterpretation. Particularly epileptic mice show altered behaviour during the test as they fail to understand the paradigm context. In the Barnes maze test, a dry-land maze test for spatial learning and memory that uses milder aversive stimuli, these drawbacks have not yet been reported. In the present study, we use this task to evaluate spatial learning and memory in the intrahippocampal kainic acid mouse model of TLE. We demonstrate that the epileptic mice understand the Barnes maze paradigm context, as they learn the location of the escape-chamber by using a serial search strategy but fail to develop the more efficient spatial search strategy. Our data indicate that the Barnes maze may be a better alternative to the Morris water maze for assessing search strategies and impairment of learning and memory in epileptic mice. |
| Databáze: | OpenAIRE |
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