Evaluation of serum folate level before and after bath PUVA therapy in patients referred to Razi Hospital, Rasht, Iran

Autor:	Kaveh Gharaei Nejad, Rana Rafiei, Elahe Rafiei, Behnam Rafiee, Leila Yousefkhani, Abbas Darjani, Narges Alizadeh, Hojat Eftekhari
Rok vydání:	2019
Předmět:	Adult Male medicine.medical_specialty Adolescent Dermatology Activity index Iran Gastroenterology 030207 dermatology & venereal diseases 03 medical and health sciences Young Adult 0302 clinical medicine Serum folate Folic Acid Psoriasis Internal medicine Medicine Humans In patient Bath puva PUVA Therapy Referral and Consultation Aged Retrospective Studies Aged 80 and over Serum folate level business.industry Significant difference General Medicine Middle Aged medicine.disease Treatment Outcome 030220 oncology & carcinogenesis Female business After treatment Biomarkers Follow-Up Studies
Zdroj:	Dermatologic therapyREFERENCES. 32(5)
ISSN:	1529-8019
Popis:	Ultraviolet (UV) radiation could disintegrate folate molecule, so phototherapy may reduce folate levels in the patients. The effect of phototherapy on serum folate in human body is questionable. We investigated the effect of bath PUVA therapy on serum folate level. This study was designed as a before-after study. Thirty-two patients completed study during 2 years. Our variables were demographic data, folate levels before and 8 weeks after treatment and cumulative dosage of UVA during 8 weeks of treatment. Serum folate was evaluated with chemiluminescence immunoassay technique. All data were analyzed using SPSS 18 software. Folate level changes were statistically significant before and after bath PUVA therapy. There was no significant difference in folate levels in psoriasis patients compared with nonpsoriasis patients. In psoriasis patients, folate levels had no significant correlation with psoriasis activity index before treatment. Decrease in folate levels was more significant in fair-skinned patients. There was no association between folate status and cumulative dosage of UVA. Bath PUVA therapy reduced serum folate level in our patients although none of them were folate deficient. Folate deficiency should be evaluated and corrected especially in fair-skinned cases, as it may be aggravated by phototherapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e55e4dc131c640507bb4cca3d989625 https://pubmed.ncbi.nlm.nih.gov/31215747 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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