Prognostic prediction of BRAF(V600E) and its relationship with sodium iodide symporter in classic variant of papillary thyroid carcinomas
| Autor: | Teng Li Song, Liu Li Wie, Wei Li Gao, Ye Guo Chao, Lu Wie |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Sodium-iodide symporter
Adult Male Proto-Oncogene Proteins B-raf medicine.medical_specialty endocrine system diseases medicine.medical_treatment DNA Mutational Analysis General Biochemistry Genetics and Molecular Biology Thyroid carcinoma Immunoenzyme Techniques Iodine Radioisotopes Internal medicine Carcinoma medicine Biomarkers Tumor Humans Clinical significance Thyroid Neoplasms Thyroid cancer Neoplasm Staging Symporters business.industry Thyroidectomy DNA Neoplasm Middle Aged medicine.disease Prognosis Carcinoma Papillary Endocrinology Thyroid Cancer Papillary Lymphatic Metastasis Mutation Cancer research Immunohistochemistry Female Radiotherapy Adjuvant Lymph Nodes Neoplasm Recurrence Local business V600E |
| Zdroj: | Clinical laboratory. 58(9-10) |
| ISSN: | 1433-6510 |
| Popis: | Background The aim of this study was to evaluate the prognosis of the classic variant of papillary thyroid carcinomas with the BRAF(V600E) mutation and 131I treatment failure in those tumors due to lower functional sodium iodide symporter expression. Methods 109 papillary thyroid carcinomas were associated with clinicopathologic features. The BRAF(V600E) mutation was evaluated by direct sequencing and sodium iodide symporter protein was determined by immunohistochemistry. Results We found that the BRAF(V600E) mutation was significantly associated with the classic variant of papillary thyroid carcinomas and was independent of tumor size, the presence of extrathyroid invasion and lymph node metastasis, advanced TMN stages, and a high risk of disease recurrence. Moreover, the BRAF(V600E) mutation was associated with a statistically significant lower functional NIS protein expression in the classic variant of papillary thyroid carcinomas. However, those statistically significant relationships were not found in the follicular variant of papillary thyroid carcinomas. Conclusions The BRAF(V600E) mutation might be associated with a more aggressive phenotype and a poor prognosis, causing less NIS-mediated 131I uptake due to a lower functional NIS protein expression in the classic variant of papillary thyroid carcinomas. Our current study appears to be valuable for predicting prognosis and is of important clinical significance for surgery and 131I treatment in patients with the classic variant of papillary thyroid carcinomas. |
| Databáze: | OpenAIRE |
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