Access to Polyfunctionalized Chiral Piperidines through Enantioselective Addition-Carbocyclization Cascade Reaction Catalyzed by a Rhodium(I)-Diene Complex

Autor:	Jean-Louis Brayer, Fabien Serpier, Benoit Folleas, Sylvain Darses
Rok vydání:	2015
Předmět:	chemistry.chemical_compound Diene chemistry Cascade reaction Organic Chemistry Enantioselective synthesis chemistry.chemical_element Physical and Theoretical Chemistry Biochemistry Combinatorial chemistry Stereocenter Rhodium Catalysis
Zdroj:	Organic letters. 17(21)
ISSN:	1523-7052
Popis:	A new addition–carbocyclization cascade reaction initiated by arylboronic acids and catalyzed by a rhodium/chiral diene complex is described. Starting from N-bridged oxoenoate derivatives, highly functionalized piperidines bearing three contiguous stereogenic centers were obtained with excellent enantio- and diastereoselectivities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e52da684f620e5c349fcf5334fb509b https://pubmed.ncbi.nlm.nih.gov/26469888 Zobrazit plný text záznamu