Preoperative prealbumin level as an independent predictor of long-term prognosis after liver resection for hepatocellular carcinoma: a multi-institutional study
| Autor: | Han Wu, Jun Han, Xin-Fei Xu, Meng-Chao Wu, Yongyi Zeng, Tian Yang, Ju-Dong Li, Feng Shen, Wan Y. Lau, Ting-Hao Chen, Hao Xing, Ya-Hao Zhou, Jiong-Jie Yu, Wei-Min Gu, Hong Wang, Chao Li |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male China medicine.medical_specialty Carcinoma Hepatocellular Time Factors Databases Factual Serum Albumin Human Risk Assessment Gastroenterology Resection 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Risk Factors Internal medicine Carcinoma Hepatectomy Humans Medicine Progression-free survival Retrospective Studies Hepatology biology business.industry Liver Neoplasms nutritional and metabolic diseases Retrospective cohort study Middle Aged medicine.disease Progression-Free Survival Transthyretin 030220 oncology & carcinogenesis Predictive value of tests Hepatocellular carcinoma biology.protein Female 030211 gastroenterology & hepatology Liver function business |
| Zdroj: | HPB. 21:157-166 |
| ISSN: | 1365-182X |
| DOI: | 10.1016/j.hpb.2018.06.1803 |
| Popis: | Serum prealbumin is a sensitive and stable marker for nutritional status and liver function. Whether preoperative prealbumin level is associated with long-term prognosis in patients undergoing liver resection for hepatocellular carcinoma (HCC) is unclear.Patients who underwent liver resection for HCC between 2001 and 2014 at six institutions were enrolled. These patients were divided into the low and normal prealbumin groups using a cut-off value of 170 mg/L for preoperative prealbumin level. The overall survival (OS) and recurrence-free survival (RFS) were compared between them.In 1483 patients, 437 (29%) had a low prealbumin level. The 3- and 5-year OS and RFS rates of patients in the low-prealbumin group were 57 and 31%, and 40 and 20%, respectively, which were significantly poorer than those in the normal-prealbumin group (76 and 43%, and 56 and 28%, respectively, both p 0.001). Multivariable Cox-regression analyses revealed that preoperative prealbumin level was an independent predictor of OS (HR, 1.45, 95% CI: 1.24-1.70, p 0.001) and RFS (HR, 1.28, 95% CI: 1.10-1.48, p 0.001).Preoperative prealbumin level could be used in predicting long-term prognosis for patients undergoing liver resection for HCC. |
| Databáze: | OpenAIRE |
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