Hyperbaric Oxygen Therapy as Adjuvant Treatment for Hardware-Related Infections in Neuromodulation
| Autor: | Michael Nekludov, Gastón Schechtmann, Jiri Bartek, Tiit Mathiesen, Folke Lind, Simon Skyrman |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Prosthesis-Related Infections medicine.drug_class medicine.medical_treatment Antibiotics 03 medical and health sciences Young Adult 0302 clinical medicine Hyperbaric oxygen medicine Intrathecal pump Infection control Humans 030212 general & internal medicine Prospective Studies Prospective cohort study Child Device Removal Aged Retrospective Studies Aged 80 and over Hyperbaric Oxygenation business.industry Middle Aged University hospital Neuromodulation (medicine) Anti-Bacterial Agents Treatment Outcome Surgery Female Neurology (clinical) business Adjuvant 030217 neurology & neurosurgery Computer hardware Follow-Up Studies |
| Zdroj: | Stereotactic and functional neurosurgery. 96(2) |
| ISSN: | 1423-0372 |
| Popis: | Background: In neuromodulation therapies, hardware-related infections are a major challenge often leading to hardware removal. Objective: To investigate the role of adjuvant hyperbaric oxygen therapy (HBOT) in hardware-related infections. Methods: Fourteen hardware-related infection events in 12 consecutive patients between 2002 and 2015 were treated with antibiotics and adjuvant HBOT at the Karolinska University Hospital (Stockholm, Sweden). Two time-independent infection events related to hardware replacements occurred in 2 patients. Infection resolution and the need for hardware removal were assessed. Results: Twelve out of 14 events of hardware-related infection were successfully treated without hardware removal (86%). The 2 patients treated twice with HBOT on 2 time-independent occasions could retain their hardware in both cases. Hardware was removed following HBOT failure in 2 infection events, with long-term infection control achieved in all patients. Further, an intrathecal pump malfunction caused by HBOT at 2.8 bars was observed, leading to a change in the manufacturer’s guidelines. Conclusions: This study indicates a potential benefit of adjuvant HBOT in the treatment of hardware-related infections in neuromodulation, diminishing the need for hardware removal and treatment interruption. Prospective studies are warranted to establish the role of adjuvant HBOT in the treatment of hardware-related infections in neuromodulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|