Reproductive history in mothers of children with neural tube defects
| Autor: | Roberto Pérez-Medina, Ingrid P. Dávalos, Olivares N, Fernando Rivas, Nory Omayra Dávalos, Guillermo Gómez-Partida, Ranajit Chakraborty |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Genetic counseling Gestational Age Environment Encephalocele Nuclear Family Pregnancy Recurrence Risk Factors Anencephaly medicine Humans Neural Tube Defects Mexico Neural tube defect business.industry Spina bifida Obstetrics Obstetrics and Gynecology medicine.disease Surgery Abortion Spontaneous Reproductive Medicine Etiology Gestation Female business Maternal Age |
| Zdroj: | Gynecologic and obstetric investigation. 49(4) |
| ISSN: | 0378-7346 |
| Popis: | The reproductive history of 100 women with at least 1 child with a neural tube defect (NTD) has been studied. The data analyzed correspond to the period previous to their first visit to a genetic counseling service. A total of 204 pregnancies resulted in 205 outcomes. Of the 100 sibships, 14 (14%) had more than 1 affected member. The pregnancy was shorter than 28 weeks in 56/205 (27%) of the total outcomes. Of 104 evaluable previous outcomes, 34 corresponded to short pregnancies, positioned before an affected (23/60, 38%), a healthy (2/18, 11%), or an undiagnosed product (9/26, 35%). Short pregnancies subsequent to affected outcomes were also increased. The inter-gestational interval varied according to diagnosis: it was longer in the affected group than in the healthy one (0.1 > p > 0.05) and the subsequent intervals were shorter for the affected group (p < 0.05). An increased number of abortions adjacent to affected offspring and a changing fertility pattern, depending on the product diagnosis, point to an environmental etiological component in this high-risk NTD group of mothers. |
| Databáze: | OpenAIRE |
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