Reference intervals for red cell variables and platelet counts in infants at 2, 5 and 13 months of age: a cohort study
| Autor: | Lynne Lennard, Adam Finn, R F Hinchliffe, G J Bellamy, F Bell, Ajay Vora |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Erythrocyte Indices
Male Pediatrics medicine.medical_specialty Anemia Iron Physiology Protoporphyrins Pathology and Forensic Medicine Blood cell Cohort Studies chemistry.chemical_compound Hemoglobins Sex Factors Reticulocyte Count Reference Values medicine Humans Thrombocytosis Red Cell business.industry Platelet Count Zinc protoporphyrin Age Factors Infant Red blood cell distribution width General Medicine medicine.disease Blood Cell Count medicine.anatomical_structure chemistry Hematocrit Cohort Female Hemoglobin business |
| Zdroj: | Journal of clinical pathology. 66(11) |
| ISSN: | 1472-4146 |
| Popis: | AimsTo derive reference values for red cell variables and platelet counts from a cohort of infants sampled at precise ages during the first 13 months of life.MethodsBlood counts, reticulocyte counts and zinc protoporphyrin concentrations were obtained from healthy term infants of North European ancestry at 2, 5 and 13 months of age.ResultsMean cell volume (MCV) and mean cell haemoglobin (MCH) values did not differ significantly between 5 and 13 months and MCH concentration was unaffected by age. Values of all other variables at any one age differed significantly from those at the other two. Haemoglobin, mean cell haemoglobin, zinc protoporphyrin and platelet values (95% ranges) at 2 (n=119), 5 (n=97) and 13 months (n=42) were, respectively, 91–125, 101–129 and 105–133 g/L; 28.6–33.1, 24.5–28.7 and 24.3–28.7 pg; 36–116, 25–91 and 27–57 micromol/mol haem; and 216–658, 241–591 and 209–455×109/L. At 2 and 5 months, respectively, 26.9% and 10.8% of subjects had platelet counts >500×109/L. Reticulocyte counts at 2 months and MCV and MCH values at 5 months were significantly higher in girls. In boys, red cell distribution width values were significantly higher at 5 months, and zinc protoporphyrin values at both 2 and 5 months.ConclusionsThese findings indicate the value of obtaining reference data at precise ages during infancy and confirm and extend earlier reports indicating a gender difference in laboratory measures used to assess iron status in early infancy. |
| Databáze: | OpenAIRE |
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