Perspectives of ruthenium(ii ) polyazaaromatic photo-oxidizing complexes photoreactive towards tryptophan-containing peptides and derivatives
| Autor: | Cécile Moucheron, Kevin Garnir, Sandra Estalayo-Adrián |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Guanine
Stereochemistry Context (language use) 010402 general chemistry 01 natural sciences Ruthenium Catalysis chemistry.chemical_compound Electron transfer Coordination Complexes Materials Chemistry chemistry.chemical_classification Aza Compounds 010405 organic chemistry Oligonucleotide Biomolecule Tryptophan Metals and Alloys General Chemistry Photochemical Processes Combinatorial chemistry 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Amino acid chemistry Ceramics and Composites Peptides Oxidation-Reduction DNA |
| Zdroj: | Chemical Communications. 54:322-337 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | RuII polyazaaromatic complexes have been studied with the aim of developing molecular tools for DNA and oligonucleotides. In this context, RuII–TAP (TAP = 1,4,5,8-tetraazaphenanthrene) complexes have been developed as specific photoreagents targeting the genetic material. The advantage of such compounds is due to the formation of photo-addition products between the Ru–TAP complex and the biomolecule, originating from a photo-induced electron transfer process that takes place between the excited Ru–TAP complex and guanine (G) bases of DNA. This photo-addition has been more recently extended to amino acids in view of applications involving peptides, such as inhibition or photocontrol of proteins. More particularly, tryptophan (Trp) and Trp-containing peptides are also able to be photo-oxidized by RuII–TAP complexes, leading to the formation of photo-addition products. This mini review focuses on recent advances in the search for RuII polyazaaromatic photo-oxidizing complexes of interest as molecular tools and photoreagents for Trp-containing peptides and proteins. Different possible future directions in this field are also discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|